摘要
Two copper(Ⅱ)complexes were obtained by solvothermal reaction induced by isonicotinic acid ligand through the study of natural simulated enzymes.The activity of superoxide dismutase(SOD)1 and 2 is higher than that of most Cu-SOD mimics,and they have the activity of catechol analogues.It is found that SOD activity and cat-echolase activity are directly affected by the coordination configuration of the central metal atom and the ability of the complex to accept electrons.It is also responsible for the excellent enzyme activity of these two Cu-based complexes.The results of MTT assay show that complexes 1 and 2 have no significant inhibitory effect on cell proliferation.It has good application potential in the clinical biomedical field in the future.
基金
supported by the National Natural Science Foundation of China(22001156,22271178,21801161)
the China Postdoctoral Science Foundation(2019M653524)
the Youth Talent Fund of University Association for Science and Technology in Shaanxi,China(20210602)
International Cooperation Key Project of Science and Technology Department of Shaanxi,China(2022KWZ-06)
the research project of Science and Technology Department of Shaanxi Province(2021JQ-533).
