Listeria monocytogenes meningitis in three immunocompetent children and a review of the literature

Objective:To summarize the clinical characteristics and treatment outcome of 3 cases of Listeria monocytogenes(Lm)meningitis in immunocompetent children,improve clinicians'awareness of the disease.Methods:The clinical features and treatment of Lm meningitis in children admitted to Children's Hospital of Zhejiang University School of Medicine from January 2016 to May 2019 were analyzed retrospectively.We summarized related literatures,and compared the selection of antibiotics in children with Lm meningitis reported in cases.Results:All patients had fever,vomiting and other symptoms,CSF as purulent meningitis performance,Ampicillin is currently the first choice of treatment,while meropenem and Linezolid could be administered as alternative drugs for Lm meningitis.Conclusions:For children with meningitis,when the empirical antibiotics treatment fill,the possibility of Lm meningitis should be considered,and antibiotics that can effectively cover Lm should be adjusted in time.