Effect of Zingiber Officinale Sucus on contraction of isolated duodenum in rabbits

Objective:Observation of ginger (Zingiber Officinale Sucus, ZOS) effect on rabbit isolated duodenum and to explore the correlation mechanism with M and H1 receptor. To investigate the effects of ZOS on isolated duodenum of rabbits treated with acetylcholine, histamine, atropine and chlorpheniramine respectively. Methods: The optimal concentration of ZOS was 1% and the above drugs were applied to the isolated duodenal segments respectively. The contractile force was recorded by BL-420E biological signal acquisition system. Results: The results showed that ZOS significantly inhibited the contraction of isolated rabbit duodenal smooth muscle in a positive concentration-dependent manner. The mechanism of inhibiting contraction had little correlation with M and H1 receptors. Conclusion: It could inhibit the efficacy of acetylcholine and histamine, and was a synergist for atropine and chlorpheniramine. This study provided a basis for the use of ginger in daily life and the development of combined medication.