摘要
Tumors employ several mechanisms to evade recognition by the immune system.Among these are epigenetic changes such as loss of the antigen presenting machinery(e.g.,HLA-A,B,C)that cause tumors to become invisible to the immune system.
基金
This study was supported by NIH grants R01CA056821,P01CA33049,and P01CA59350,and MSKCC Cancer Center Core Grant P30CA008748.This study was supported by funding from Ludwig Institute for Cancer Research,Swim Across America,Parker Institute for Cancer Immunotherapy,Howard Hughes Medical Institute and the Breast Cancer Research Foundation.
