摘要
Since the adoption of Milan criteria more than 20 years ago,selection criteria for liver transplantation(LT)in patients suffering from hepatocellular carcinoma(HCC)represented a debated issue.Halazun and colleagues presented at the American Surgical Association of 2018,and published on the issue of October of Annals of Surgery,their results from an analysis aimed at including alpha-fetoprotein(AFP)in a model developed to predict long-term results after LT for HCC(1).Of 1,450 patients included between 2001 and 2013,16.2%were outside Milan criteria,61.1%were hepatitis C virus(HCV)positive and more than 80%of candidates received pre-LT locoregional therapies.Their study showed that incorporating AFP levels at diagnosis,maximum AFP(Max-AFP)at any time point,and the final immediate pre-transplant AFP(Final-AFP)to tumor number and diameter can well stratify different groups of patients at different risks of HCC recurrence after LT(NYCA model).
