Overview of the application of nucleotide in aquaculture

Although long history application in infant formula,dietary nucleotide supplementation has been used only recently in the evaluation of growth performance,stress and pathogen resistance in aquaculture species.This paper addresses the present knowledge of the use of nucleotide supplemented in the diet for culture species.Research reveals that dietary nucleotide may have significant impact and is recommended to add to the feed of aquatic species to get better performance.However,more studies should also be conducted to have better understandings on dose requirement,duration of application,impact on different life stage and under different environmental stress and pathogens.Further study should also examine the effects of dietary nucleotide supplementation of intestinal microbiota and gut morphology,and immune response of aquaculture species.