摘要
Objective:To examine metabolic disorders of major components of organic basis of bone tissue in patients with chronic hematogenous osteomyelitis and response to surgical treatment.Methods:The cubital vein puncture was conducted to take blood for analysis in patients with chronic hematogenous osteomyelitis.The activity of collagenase and hyaluronidase,elastin,elastase and total content of glycosaminoglycans were measured in blood serum.Results:The study revealed an enhancement of catabolic phase of metabolism of the main components in bone organic matrix during the relapse of inflammation.It was evidenced by indicators reflecting the synthetic and catabolic phases of the main components of the connective tissue collagen and glycosaminoglycans.The effective therapeutic treatments led to the reduction and normalization of studied compounds.Conclusions:The initial development of hematogenous osteomyelitis happens in a background of metabolic disorders of the main components of organic matrix of bone tissue,and normalizes upon effective therapy.
基金
Supported by Institute of Traumatology and Orthopedics of the National Academy of Medical Sciences of Ukraine(Grant No.0103U001318).
