摘要
Objective:To evaluate the effect of the antithyroid drug,carbimazole on liver of albino rats and the possible ameliorative role of selenium.Methods:Four groups of rats were used(n=10),Group 1 served as normal control,Group 2 was orally given sodium selenite(10μg/kg body weight)daily for 8 weeks,Group 3 was orally given carbimazole at a dose level of 1.35 mg/kg body weight,Group 4 was orally administered carbimazole and sodium selenite daily for 8 weeks.Rats in control and treated groups were sacrificed by cervical decapitation after 8 weeks of treatment,their livers were removed and stained with H&E for histological examinations.Alanine aminotransferase and aspartate aminotransferase were determined in the sera.Malondialdehyde and the antioxidant enzymes,catalase and superoxide dismutase were measured in the liver.Results:Cytoplasmic vacuolation of the hepatocytes,necrosis,leucocytic infiltrations,blood vessels congestion and fatty degeneration were observed in liver of carbimazole-treated animals.Carbimazole caused marked elevation in serum alanine aminotransferase and aspartate aminotransferase.It also caused an increase in malondialdehyde and depletion of the activity of the antioxidant enzymes,catalase and superoxide dismutase in the liver.Treating animals with carbimazole and selenium led to an improvement in both the histological and biochemical alterations induced by carbimazole.Moreover,selenium reduced the level of malondialdehyde and increased the activity of antioxidant enzymes,superoxide dismutase and catalase.Conclusions:It is concluded that the ameliorative effect of selenium against the hepatotoxicity of carbimazole is attributed to its antioxidant properties.
