胃复春片与兰索拉唑联合治疗慢性萎缩性胃炎的疗效及对患者血清炎症指标水平的影响

Therapeutic Effect of the Combination of Weifuchun Tablets and Lansoprazole in the Treatment of Chronic Atrophic Gastritis and Its Impact on the Serum Inflammatory Index Levels of Patients

目的探究胃复春片与兰索拉唑联合治疗慢性萎缩性胃炎(CAG)的疗效及对患者血清炎症指标水平的影响.方法选择该院2022年4-2023年9月收治的70例CAG患者为研究对象,按随机数字表法将其分为对照组与观察组,各35例.在常规治疗的基础上,对照组给予患者兰索拉唑肠溶片治疗,观察组给予患者兰索拉唑肠溶片联合胃复春片治疗.对比两组患者的血清炎症指标、胃肠激素水平、症状评分及不良反应发生情况.结果治疗后,观察组超敏C反应蛋白、白细胞介素-6、肿瘤坏死因子-α、白细胞介素-8水平均低于对照组,组间差异有统计学意义(P<0.05);观察组胃泌素水平为(44.37±7.61)pg/mL,低于对照组的(69.54±5.73)pg/mL,胃动素水平为(343.36±35.49)pg/mL,高于对照组的(298.40±28.04)pg/mL,组间差异有统计学意义(P<0.05);观察组胃脘胀满、乏力、隐痛和纳差证候评分均低于对照组,组间差异有统计学意义(P<0.05).两组不良反应发生率对比,差异无统计学意义(P>0.05).结论胃复春片联合拉索拉唑联合治疗CAG的疗效较佳,能够改善胃肠激素水平,缓解炎症反应,降低症状评分.

Objective To explore the therapeutic effect of the combination of Weifuchun tablets and Lansoprazole in the treatment of chronic atrophic gastritis(CAG)and its impact on serum inflammatory markers in patients.Methods 70 CAG patients admitted to the hospital from April 2022 to September 2023 were selected as the study objects,and were divided into a control group and an observation group according to random number table method,with 35 cases in each group.On the basis of conventional treatment,patients in the control group were treated with Lansoprazole enteric-coated tablets,and patients in the observation group were treated with Lansoprazole enteric-coated tablets combined with Weifuchun tablets.Serum inflammatory indexes,gastrointestinal hormone levels,symptom scores and the occurrence of adverse reactionswere compared between the two groups.Results After treatment,the levels of hypersensitive C-reactive protein,interleukin-6,tumor necrosis factor-αand interleukin-8 in observation group were lower than those in control group,with statistical significance(P<0.05);gastrin level in the observation group was(44.37±7.61)pg/mL,lower than(69.54±5.73)pg/mL in the control group,and motilin level was(343.36±35.49)pg/mL,higher than(298.40±28.04)pg/mL in the control group,the differences between groups were statistically significant(P<0.05);the syndrome scores of epigastric fullness,weakness,dull pain and poor appetite in the observation group were lower than those in the control group,and the differences between groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of Weifuchun tablets and Lasoprazole has a better therapeutic effect on CAG,which can improve gastrointestinal hormone levels,alleviate inflammatory reactions,and reduce symptom scores.