药物涂层球囊与药物洗脱支架在冠心病患者行冠状动脉介入治疗中的应用价值比较

Comparison of the Application Value of Drug-Coated Balloons and Drug-Eluting Stents in Coronary Intervention Treatment in Patients with Coronary Heart Disease

目的对比药物涂层球囊与药物洗脱支架对行冠状动脉介入治疗(PCI)的冠心病患者的影响.方法选取2021年1月—2022年12月该院收治的150例行PCI治疗的冠心病患者为研究对象,按随机数字表法将其分为对照组与观察组,各75例.对照组行药物洗脱支架,观察组行药物涂层球囊.对比两组患者的再狭窄发生率、心功能、主要心血管不良事件(MACE)发生率.结果观察组再狭窄发生率为4.00%,MACE发生率为2.67%,均低于对照组的13.89%、12.00%,组间差异有统计学意义(P<0.05).术后1年,观察组左室收缩末期内径为(38.71±2.83)mm,左室舒张末期内径为(42.46±3.74)mm,均短于对照组的(45.89±3.26)mm、(49.71±4.26)mm,左室射血分数为(59.53±5.29)%,高于对照组的(53.48±4.76)%,每搏输出量为(70.31±6.18)mL,多于对照组的(64.25±5.29)mL,组间差异有统计学意义(P<0.05).结论药物涂层球囊更能够改善行PCI的冠心病患者心功能,降低再狭窄率与MACE发生率,有一定的应用价值,值得临床进行推广应用.

Objective To compare the effects of drug-coated balloon and drug-eluting stent on coronary heart disease patients undergoing percutaneous coronary intervention(PCI).Methods 150 patients with coronary heart disease who underwent PCI treatment in our hospital from January 2021 to December 2022 were selected as the study objects,and were divided into a control group and an observation group according to random number table method,with 75 cases in each group.The control group received drug-eluting stent,and the observation group received drug-coated balloon.The incidence of restenosis,heart function and Major Adverse Cardiovascular Events(MACE)were compared between the two groups.Results The incidence of restenosis and MACE in the observation group was 4.00%and 2.67%,both lower than 13.89%and 12.00%in the control group,with statistical significance(P<0.05).One year after surgery,the left ventricular end-systolic diameter in the observation group was(38.71±2.83)mm,and the left ventricular end-diastolic diameter was(42.46±3.74)mm,both of which were shorter than(45.89±3.26)mm and(49.71±4.26)mm in the control group,the left ventricular ejection fraction was(59.53±5.29)%,higher than(53.48±4.76)%of the control group,and the stroke output was(70.31±6.18)mL,more than(64.25±5.29)mL of the control group,the differences were statistically significant(P<0.05).Conclusion The drug-coated balloon can improve the heart function of coronary heart disease patients undergoing PCI,reduce the restenosis rate and the incidence of MACE,which has certain application value and is worthy of clinical promotion and application.