苏黄止咳胶囊联合头孢他啶治疗慢性支气管炎急性发作期的临床效果探讨

Clinical Effect of Suhuang Zhike Capsule Combined with Ceftazidime in the Treatment of Acute Exacerbation of Chronic Bronchitis

目的探讨苏黄止咳胶囊与头孢他啶联合治疗慢性支气管炎(CB)急性发作期患者的效果.方法选择我院2020年4月—2023年11月收治的86例CB急性发作期患者为研究对象,采用随机数表法将其分成对照组和观察组,各43例.对照组采用注射用头孢他啶治疗,观察组加用苏黄止咳胶囊治疗.对比两组中医证候积分、症状消失时间、炎症反应、肺功能、不良反应发生情况.结果治疗后,观察组中医证候积分低于对照组,临床症状消失时间短于对照组,组间差异有统计学意义(P<0.05).治疗后,观察组超敏C反应蛋白、肿瘤坏死因子、白细胞介素-6水平均低于对照组,用力肺活量、第1秒用力呼气容积均大于对照组,1秒率高于对照组,组间差异有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论苏黄止咳胶囊与头孢他啶联合应用于CB急性发作期患者中,可增强疗效,促进患者恢复,减轻炎症反应,提高肺功能水平,且不增加不良反应发生率.

Objective To investigate the effect of Suhuang Zhike capsule combined with ceftazidime in the treatment of patients with acute exacerbation of chronic bronchitis(CB).Methods 86 patients with acute exacerbation of CB treated in our hospital from April 2020 to November 2023 were selected as the research objects and they were randomly divided into a control group and an observation group,43 cases in each group.The control group was treated with ceftazidime for injection,and the observation group was treated with Suhuang Zhike capsule.TCM syndrome score,symptom disappearance time,inflammatory reaction,lung function and adverse reactions were compared between the two groups.Results After treatment,the TCM syndrome score of the observation group was lower than that of the control group,and the disappearance time of clinical symptoms was shorter than that of the control group,with statistical significance(P<0.05).After treatment,the levels of high-sensitivity C-reactive protein,tumor necrosis factor a,and interleukin-6 were lower than those in the control group,and the vital capacity,first second expiratory volume were greater than those in the control group,and one-second rate was higher than that in the control group,with statistical significance(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Suhuang Zhike capsule combined with ceftazidime in the treatment of patients with acute exacerbation of CB can enhance the curative effect,promote the recovery of patients,reduce the inflammatory reaction,improve the level of lung function,and not increase the incidence of adverse reactions.