乳酸菌阴道胶囊联合重组人干扰素α-2b凝胶治疗细菌性阴道炎合并HPV感染患者的效果观察

Effect of Lactic Acid Bacteria Vaginal Capsule Combined with Recombinant Human Interferon α-2b Gel on Patients with Bacterial Vaginitis Complicated with HPV Infection

目的探讨乳酸菌阴道胶囊联合重组人干扰素α-2b凝胶治疗细菌性阴道炎合并人乳头瘤病毒(HPV)感染患者的临床效果.方法选择2022年9月—2023年9月惠水县人民医院收治的92例细菌性阴道炎合并HPV患者为研究对象,按随机数字表法将其分为对照组与观察组,各46例.对照组采用重组人干扰素α-2b凝胶治疗,观察组在对照组基础上联合乳酸菌阴道胶囊治疗,两组均持续干预2个月.比较两组HPV转阴率、临床症状积分、炎症反应、不良反应发生情况.结果治疗2个月后,观察组HPV转阴总有效率为95.65%,高于对照组的82.62%,差异有统计学意义(P<0.05).观察组白带增多、白带腥臭、阴道瘙痒症状评分均低于对照组,组间差异有统计学意义(P<0.05).观察组TNF-α、CRP、IL-4、IL-6、IFN-γ水平均低于对照组,组间差异有统计学意义(P<0.05).两组不良反应发生情况比较,差异无统计学意义(P>0.05).结论乳酸菌阴道胶囊联合重组人干扰素α-2b凝胶治疗细菌性阴道炎合并HPV感染患者能够减轻其临床症状、炎症反应,提高HPV转阴率,且安全性高.

Objective To investigate the clinical effect of lactic acid bacteria vaginal capsule combined with recombinant human interferonα-2b gel on patients with bacterial vaginitis complicated with human papillomavirus(HPV)infection.Methods 92 patients with bacterial vaginitis complicated with HPV admitted to Huishui County People's Hospital from September 2022 to September 2023 were selected as the study objects,and were divided into a control group and an observation group according to random number table method,with 46 cases in each group.The control group was treated with recombinant human interferonα-2b gel,and the observation group was treated with lactic acid bacteria vaginal capsule on the basis of the control group.The intervention lasted for 2 months in both groups.HPV negative conversion rate,clinical symptom score,inflammatory response and adverse reaction were compared between the two groups.Results After 2 months of treatment,the total effective rate of HPV negative conversion in the observation group was 95.65%,which was higher than 82.62%in the control group,and the difference was statistically significant(P<0.05).The symptom scores of increased leucorrhea,smelly leucorrhea and pruritus in observation group were lower than those in control group,and the differences between groups were statistically significant(P<0.05).TNF-α,CRP,IL-4,IL-6 and IFN-γin observation group were lower than those in control group,and the differences between groups were statistically significant(P<0.05).There was no significant difference in the occurrence of adverse reactions between the two groups(P>0.05).Conclusion Lactic acid bacteria vaginal capsule combined with recombinant human interferonα-2b gel in the treatment of bacterial vaginitis complicated with HPV infection can reduce the clinical symptoms,inflammatory response,improve the rate of HPV negative,and high safety.