腹腔镜下前列腺癌根治手术对早期前列腺癌患者尿流动力学指标及术后并发症的影响

Effects of Laparoscopic Radical Prostatectomy on Urodynamic Indicators and Postoperative Complications in Early Prostate Cancer Patients

目的分析腹腔镜下前列腺癌根治手术(LRP)在早期前列腺癌(PCa)患者中的应用效果.方法选取2021年6月—2023年6月聊城市东昌府区中医院收治的86例早期PCa患者为研究对象,按随机数字表法分为对照组及观察组,每组43例.对照组行传统开放性手术,观察组行LRP,术后观察3个月.对比两组患者的围术期指标、症状严重程度、尿流动力学指标、生活质量及并发症发生情况.结果观察组的术中出血量为(263.41±21.25)mL,少于对照组的(324.59±25.97)mL,手术时间为(175.68±16.53)min,长于对照组的(124.26±12.49)min,引流管留置时间、住院时间分别为(3.21±0.72)d、(11.25±1.68)d,均短于对照组的(5.61±1.59)d、(15.41±2.39)d,组间差异有统计学意义(P<0.05).术后,观察组的膀胱顺应性高于对照组,残余尿量少于对照组,最大尿流率大于对照组,组间差异有统计学意义(P<0.05).术后,观察组的国际前列腺症状量表评分低于对照组,世界卫生组织生存质量测定量表简表内各维度评分均高于对照组,组间差异有统计学意义(P<0.05).观察组的并发症发生率为4.65%,低于对照组的20.93%,差异有统计学意义(P<0.05).结论LRP可减轻早期PCa症状,改善患者尿流动力学,提高其生活质量,且并发症少.

Objective To analyze the effects of laparoscopic radical prostatectomy(LRP)in patients with early prostate cancer(PCa).Methods 86 patients with early PCa admitted to Dongchangfu District Traditional Chinese Medicine Hospital in Liaocheng City from June 2021 to June 2023 were selected as the study objects and were divided into a control group and an observation group by random number table method,with 43 cases in each group.The control group received traditional open surgery,the observation group received LRP.All patients were observed for 3 months.The perioperative indexes,severi-ty of symptoms,urodynamics indexes,quality of life and complications were compared between the two groups.Results The intraoperative blood loss in the observation group was(263.41±21.25)mL,which was less than(324.59±25.97)mL in the con-trol group,the operative time was(175.68±16.53)min,longer than(124.26±12.49)min in the control group,the drainage catheter indentation time and hospital stay were(3.21±0.72)d and(11.25±1.68)d,respectively,which were shorter than(5.61±1.59)d and(15.41±2.39)d in the control group,and the differences between the groups were statistically significant(P<0.05).After operation,the bladder compliance of the observation group was higher than that of the control group,the post-void residual urine volume was lower than that of the control group,and the maximum urine flow rate was higher than that of the control group,and the differences between the groups were statistically significant(P<0.05).After surgery,the scores of the international prostate symptom score in the observation group was lower than that in the control group,and the scores of all dimensions in the World Health Organization Quality of Life-BREF scale were higher than those in the control group,and the differences between the groups were statistically significant(P<0.05).The incidence of complications in the observation group was 4.65%,which was lower than 20.93%in the control group,and the difference was statistically significant(P<0.05).Con-clusion LRP can alleviate the symptoms of early PCa,improve the urinary fluidity,improve the quality of life of patients with fewer complications.