乳果糖口服液联合复方嗜酸乳杆菌片治疗便秘型肠易激综合征的效果观察

Effect of Lactulose Oral Liquid Combined with Compound Lactobacillus Acidophilus Tablets in the Treatment of Constipated Irritable Bowel Syndrome

目的探讨乳果糖口服液联合复方嗜酸乳杆菌片在便秘型肠易激综合征(IBS-C)患者中的应用效果.方法选取2021年4月—2023年3月山东省济南市章丘区中医医院收治的150例IBS-C患者为研究对象,按随机数字表法将其分为观察组和对照组,各75例.对照组予以复方嗜酸乳杆菌片,观察组加用乳果糖口服液.对比两组临床疗效、症状积分、胃肠激素水平、生活质量及不良反应发生率.结果观察组治疗总有效率96.00%高于对照组的86.67%,差异有统计学意义(P<0.05).治疗后,两组腹胀、腹痛、大便干结、排便困难评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05).治疗后,两组胃动素、生长抑素、血管活性肠肽、血浆神经肽Y水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论乳果糖口服液联合复方嗜酸乳杆菌片能够增强IBS-C治疗效果,减轻症状,改善胃肠激素水平,且安全性高.

Objective To explore the therapeutic effect of lactulose oral solution combined with compound lactobacillus acidophilus tablets in patients with constipated irritable bowel syndrome(IBS-C).Methods 150 patients with IBS-C admitted to Zhangqiu District Traditional Chinese Medicine Hospital in Jinan City,Shandong Province from April 2021 to March 2023 were selected as the study objects and randomly divided into an observation group and a control group,with 75 patients in each group.The control group was given compound Lactobacillus acidophilus tablets,while the observation group was given lactulose oral solution.Compare the clinical efficacy,symptom score,gastrointestinal hormone levels,quality of life,and incidence of adverse reactions between two groups.Results The total effective rate of the observation group was 96.00%,which was higher than the control group's 86.67%,and the difference was statistically significant(P<0.05).After treatment,the scores of abdominal distension,abdominal pain,dry stools,and difficulty in defecation in both groups were lower than before treatment,and the observation group was lower than the control group,with statistical significance(P<0.05).After treatment,the levels of motilin,somatostatin,vasoactive intestinal peptide,and plasma neuropeptide Y in both groups were lower than before treatment,and the observation group was lower than the control group,with statistical significance(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of lactulose oral solution and compound lactobacillus acidophilus tablets can enhance the therapeutic effect of IBS-C,alleviate symptoms,improve gastrointestinal hormone levels,and have high safety.