氨溴索联合布地奈德雾化吸入治疗新生儿肺炎的临床效果

Clinical Efficacy of Ambroxol Combined with Budesonide Nebulized Inhalation in the Treatment of Neonatal Pneumonia

目的探讨氨溴索联合布地奈德雾化吸入治疗新生儿肺炎的临床效果.方法选取该院2022年1-12月收治的102例肺炎新生儿为研究对象,按照奇偶数字法将其随机分为观察组和对照组,每组51例.对照组应用布地奈德雾化吸入治疗,观察组应用氨溴索联合布地奈德雾化吸入治疗.比较两组患儿的肺功能、炎症因子水平、不良反应发生情况.结果治疗后,观察组呼气峰值流速(6.91±0.68)L/s、第1秒用力呼气容积(3.61±0.62)L均大于对照组的(5.13±0.87)L/s、(2.26±0.43)L,组间差异有统计学意义(P<0.05).治疗后,观察组患儿肿瘤坏死因子-α(16.34±5.85)pg/mL、白细胞介素-6(55.13±24.82)pg/mL及超敏C反应蛋白(15.23±5.14)mg/L水平均低于对照组的(26.25±6.41)pg/mL、(101.89±25.76)pg/mL、(20.15±6.13)mg/L,组间差异有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论氨溴索联合布地奈德雾化吸入治疗新生儿肺炎的临床效果显著,能够有效提高患儿的肺功能,缓解炎性反应,并且不会增加不良反应.

Objective To explore the clinical effect of ambroxol combined with budesonide nebulization inhalation in the treatment of neonatal pneumonia.Methods 102 newborns with pneumonia admitted to the hospital from January to December 2022 were selected as the research objects and randomly divided into an observation group and a control group using the odd even number method,with 51 cases in each group.The control group was treated with budesonide inhalation,while the observation group was treated with ambroxol combined with budesonide nebulization inhalation.Compare the lung function,inflammatory factor levels,and incidence of adverse reactions between two groups of children.Results After treatment,the peak expiratory flow rate(6.91±0.68)L/s and forced expiratory volume(3.61±0.62)L in the observation group were greater than(5.13±0.87)L/s,(2.26±0.43)L of the control group,with statistically significant differences between the groups(P<0.05).After treatment,the levels of tumor necrosis factor-α(16.34±5.85)pg/mL,interleukin-6(55.13±24.82)pg/mL,and hypersensitive C-reactive protein(15.23±5.14)mg/L in the observation group were lower than(26.25±6.41)pg/mL,(101.89±25.76)pg/mL,and(20.15±6.13)mg/L in the control group,and the differences between the groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion The clinical effect of ambroxol combined with budesonide nebulization inhalation in the treatment of neonatal pneumonia is significant,which can effectively improve the lung function of children,alleviate inflammatory reactions,and do not increase adverse reactions.