地屈孕酮联合黄体酮治疗黄体功能不全先兆流产患者的效果观察

Observation on the Efficacy of Combination Therapy with Dydrogesterone and Progesterone in the Treatment of Threatened Miscarriage Patients with Luteal Insufficiency

目的探讨地屈孕酮与黄体酮应用于黄体功能不全先兆流产患者中的效果.方法选择本院2021年4月—2023年4月收治的82例黄体功能不全先兆流产患者为研究对象,按随机数字表法将其分为对照组和观察组,每组41例.对照组采用黄体酮治疗,观察组在对照组基础上加用地屈孕酮治疗,持续治疗2周.对比两组的临床疗效、性激素水平、临床症状消失时间及不良反应发生情况.结果观察组治疗总有效率为95.12%,高于对照组的75.61%,差异有统计学意义(P<0.05).治疗后,观察组人绒毛膜促性腺激素(HCG)、血清孕酮(P)水平均高于对照组,组间差异有统计学意义(P<0.05);治疗后,观察组阴道流血、腰部疼痛及腹部疼痛消失时间均短于对照组,组间差异有统计学意义(P<0.05).两组不良反应发生率比较,组间差异无统计学意义(P>0.05).结论地屈孕酮结合黄体酮有利于增强黄体功能不全先兆流产患者的疗效,可对HCG及P水平进行有效调节,同时能减轻患者的临床症状,使保胎结局得以改善,具有良好的安全性.

Objective To explore the effect of using dydrogesterone and progesterone in patients with threatened miscarriage due to luteal insufficiency.Methods 82 patients with threatened miscarriage due to luteal insufficiency admitted to our hospital from April 2021 to April 2023 were selected as the study subjects,divided into a control group and an observation group using a random number table method,with 41 cases in each group.The control group received progesterone,while the observation group was supplemented with dydrogesterone in addition to the control group,continuous treatment for 2 weeks.The clinical efficacy,sex hormone levels,disappearance time of clinical symptoms,and adverse reactions between the two groups were compared.Results The total effective rate of treatment in the observation group was 95.12%,which was higher than 75.61%in the control group,the difference between groups were statistically significant(P<0.05).After treatment,the levels of human chorionic gonadotropin(HCG)and serum progesterone(P)in the observation group were higher than those in the control group,the differences between groups were statistically significant(P<0.05).After treatment,the observation group had a shorter disappearance time for vaginal bleeding,lower back pain,and abdominal pain compared to the control group,the differences between groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reaction between groups(P>0.05).Conclusion The combination of dydrogesterone and progesterone is beneficial for enhancing the therapeutic effect of threatened miscarriage patients with luteal insufficiency,effectively regulating HCG and P levels,reducing clinical symptoms,and improving the outcome of pregnancy preservation,and it has good safety.