丁苯酞软胶囊与胞磷胆碱联合治疗脑梗死后血管性痴呆的疗效观察

Observation on the Curative Effect of Combination of Butylphthalein Softgel Capsule and Citicoline on Vascular Dementia after Cerebral Infarction

目的探究对脑梗死后血管性痴呆患者采用丁苯酞软胶囊与胞磷胆碱联合治疗的影响.方法选择2021年4月—2023年4月菏泽中医院收治的80例脑梗死后血管性痴呆患者为研究对象,将其随机分为对照组与观察组,各40例.对照组采用胞磷胆碱治疗,观察组采用丁苯酞软胶囊联合胞磷胆碱治疗,均持续治疗2个月.比较两组临床疗效、认知功能与痴呆程度、脑循环动力学指标与血清同型半胱氨酸(Hcy)水平、生活质量及不良反应发生情况.结果治疗后,观察组临床总有效率为95.00%,高于对照组的77.50%,简易精神状况检查量表评分、中文版简明健康状况调查表评分均高于对照组,平均血流量多于对照组,平均血流速快于对照组,痴呆程度量表评分及血清Hcy水平均低于对照组,组间差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05).结论对脑梗死后血管性痴呆患者采用丁苯酞软胶囊与胞磷胆碱联用的治疗效果显著,患者认知功能及痴呆程度可得到改善,还可调节脑循环动力学指标及血清Hcy水平,提高生活质量,用药安全性高.

Objective To explore the effect of combined treatment of buphthalein softgel and citicoline on patients with vascular dementia after cerebral infarction.Methods 80 patients with vascular dementia after cerebral infarction treated in Heze Hospital of Traditional Chinese Medicine from April 2021 to April 2023 were selected as the study objects and randomly divided into a control group and an observation group,with 40 cases in each group.The control group was treated with citicoline,and the observation group was treated with butylphthalein softgel combined with citicoline for 2 months.The clinical efficacy,cognitive function and dementia degree,cerebral circulation dynamics index,serum homocysteine(Hcy)level,quality of life and adverse reactions were compared between the two groups.Results After treatment,the total clinical effective rate of the observation group was 95.00%,which was higher than 77.50%of the control group,the score of Mini Mental Status Examination and the MOS item Short From health survey were higher than those of the control group,the average blood flow was higher than that of the control group,and the average blood velocity was faster,the score of clinical Dementia Rating and serum Hcy level were lower than those of control group,and the differences between groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of butylphthalein soft capsule and citicoline has significant therapeutic effect on patients with vascular dementia after cerebral infarction.The cognitive function and dementia degree of patients can be improved,and the cerebral circulation dynamic index and serum Hcy level can be adjusted,so as to improve the quality of life and the drug is safe.