摘要
目的分析参芪麦味地黄汤联合二甲双胍在2型糖尿病(T2DM)气阴两虚证患者中的效果.方法选取2020年1月—2023年6月该院收治的70例T2DM气阴两虚证患者为研究对象,按随机数字表法将其分为对照组与观察组,各35例.对照组患者给予二甲双胍治疗,观察组在对照组基础上加以参芪麦味地黄汤治疗,持续治疗12周.比较两组临床疗效、中医证候评分、糖代谢指标、不良反应发生情况.结果观察组治疗总有效率为94.29%,高于对照组的77.14%,差异有统计学意义(P<0.05).治疗前,两组咽干口燥、倦怠乏力、气短懒言、五心烦热评分与空腹血糖(FBG)、餐后2h血糖(2 hPBG)、糖化血红蛋白(HbA1c)相比,组间差异无统计学意义(P>0.05);治疗后,观察组咽干口燥评分为(1.59±0.26)分,倦怠乏力评分为(1.15±0.20)分,气短懒言评分为(1.36±0.19)分,五心烦热评分为(1.25±0.11)分,FBG为(6.31±0.94)mmol/L,2 hPBG为(8.15±1.21)mmol/L,HbA1c为(6.25±0.87)%,均低于对照组的(2.39±0.35)分、(1.66±0.31)分、(2.25±0.28)分、(2.08±0.19)分、(7.56±1.25)mmol/L、(10.39±1.54)mmol/L、(7.39±1.05)%,组间差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05).结论参芪麦味地黄汤联合二甲双胍可减轻T2DM气阴两虚证患者症状,调节糖代谢,且无严重不良反应.
Objective To analyze the effect of Shenqi Maiwei Dihuang Decoction combined with metformin in patients with type 2 diabetes mellitus(T2DM)with Qi-Yin deficiency syndrome.Methods 70 T2DM patients with qi and Yin deficiency syndrome admitted to the hospital from January 2020 to June 2023 were selected as the research objects.According to the random number table method,they were divided into a control group and an observation group,with 35 cases in each group.The control group was treated with metformin,and the observation group was treated with Shenqi Maiwei Dihuang decoction on the basis of the control group.The treatment lasted for 12 weeks.The clinical efficacy,TCM syndrome score,glucose metabolism index and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 94.29%,which was higher than 77.14%of the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the scores of dry throat,fatigue,shortness of breath,lazy speech,and five irritability,fasting blood glucose(FBG),2 h postprandial blood glucose(2 hPBG),and glycosylated hemoglobin(HbA1c)between the two groups(P>0.05);after treatment,the score of dry throat and dry mouth in the observation group was(1.59±0.26)points,the score of tiredness and fatigue was(1.15±0.20)points,the score of shortness of breath and lazy speech was(1.36±0.19)points,and the score of five upset was(1.25±0.11)points,FBG was(6.31±0.94)mmol/L,2 hPBG was(8.15±1.21)mmol/L,HbA1c was(6.25±0.87)%.which were lower than(2.39±0.35)points,(1.66±0.31)points,(2.25±0.28)points,(2.08±0.19)points,(7.56±1.25)mmol/L,(10.39±1.54)mmol/L,(7.39±1.05)%of the control group,the differences between the two groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Shenqi Maiwei Dihuang Decoction plus metformin can alleviate the symptoms of T2DM patients with Qi-Yin deficiency syndrome,regulate glucose metabolism,and no serious adverse reactions.
作者
李振
王丽
LI Zhen;WANG Li(Department of Pharmacy,Jinan Jiyang district Hospital of traditional Chinese Medicine,Jinan Shandong,251400,China)
出处
《反射疗法与康复医学》
2024年第2期23-25,29,共4页
Reflexology And Rehabilitation Medicine
关键词
2型糖尿病
气阴两虚证
参芪麦味地黄汤
二甲双胍
糖代谢
不良反应
Type 2 diabetes
Qi and Yin deficiency syndrome
Shenqi Maiwei Dihuang Decoction
Metformin
Glucose metabolism
Adverse reactions