妥布霉素地塞米松眼膏联合除风益损汤治疗白内障术后干眼症的临床研究

Clinical Study on the Combination of Tobramycin Dexamethasone Eye Ointment and Wind-Eliminating Boosting Decoction in the Treatment of Dry Eye Syndrome after Cataract Surgery

目的分析妥布霉素地塞米松眼膏联合除风益损汤治疗白内障术后干眼症的临床研究.方法选取2021年8月—2023年8月该院收治的100例白内障术后干眼症患者为研究对象,采用随机数字表法将其分为对照组和研究组,每组50例.对照组采用玻璃酸钠滴眼液常规治疗,研究组在对照组的基础上增加妥布霉素地塞米松眼膏联合除风益损汤治疗.比较两组的治疗总有效率、基础泪液分泌试验(SIT)距离、角膜荧光素染色(CFS)评分、眼表疾病指数(OSDI)问卷、泪膜破裂时间(BUT)、炎症因子水平、不良反应发生情况.结果研究组的治疗总有效率为98.00%,高于对照组的84.00%,差异有统计学意义(P<0.05).治疗后,研究组的SIT、BUT均长于对照组,CFS、OSDI评分均低于对照组,白细胞介素-6、肿瘤坏死因子-α水平均低于对照组,组间差异有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论对白内障术后干眼症患者使用妥布霉素地塞米松眼膏联合除风益损汤治疗具有显著疗效,可促进其康复,可改善患者眼表功能,减轻炎症反应,并且具有较高的安全性.

Objective The clinical study of tobramycin dexamethasone eye ointment combined with Wind-Eliminating Boosting Decoction for dry eye syndrome after cataract surgery was analyzed.Methods Selecting 100 patients with dry eye syndrome after cataract surgery admitted to the hospital from August 2021 to August 2023 as the research subjects,divided into a control group and a study group using a random number table method,with 50 cases in each group.The control group was routinely treated with sodium hyaluronate eye drops,and the study group added tobramycin dexamethasone eye ointment to the control group.Compare the total effective rate,Schirmer I Test(SIT)distance,Corneal Fluorescein Staining(CFS)Score,Ocular Surface Disease Index(OSDI)Questionnaire,Break Up Time(BUT),inflammatory cytokine levels,and adverse reactions between two groups.Results The total effective rate of the research group was 98.00%,higher than 84.00%of the control group,the difference between groups was statistically significant(P<0.05).The SIT and BUT of the study group were longer than those of the control group,and the CFS and OSDI scores were lower than those of the control group,interleukin-6,tumor necrosis factor-αlevel lower than the control group IL-6,the differences between groups were statistically significant(P<0.05).Comparison of incidence rates of adverse reactions between two groups,there was no statistically significant difference between groups(P>0.05).Conclusion The use of tobramycin dexamethasone eye ointment combined with Wind-Eliminating Boosting Decoction in the treatment of dry eye syndrome after cataract surgery has significant therapeutic effects,can promote their recovery,improve the patient's ocular surface function,reduce inflammatory reactions,and has high safety.