人免疫球蛋白结合美罗培南治疗对新生儿败血症患儿症状改善时间、免疫功能指标的影响

The Effect of Human Immunoglobulin Combined with Meropenem Treatment on Symptom Improvement Time and Immune Function Indicators in Neonatal Sepsis Patients

目的探究人免疫球蛋白结合美罗培南治疗对新生儿败血症的影响.方法选择2022年8月—2023年8月本院收治的60例新生儿败血症患儿为研究对象,按随机数表法分为对照组和观察组,每组30例.对照组接受美罗培南治疗,观察组采用人免疫球蛋白结合美罗培南治疗,两组均持续治疗10 d.对比两组的免疫功能指标、临床疗效、症状改善时间、炎症因子水平.结果治疗后,观察组临床总有效率高于对照组,差异有统计学意义(P﹤0.05);观察组体温、拒奶、神经系统症状的改善时间及血培养转阴时间、住院时间均短于对照组,组间差异有统计学意义(P﹤0.05);观察组免疫球蛋白A、免疫球蛋白G、免疫球蛋白M水平均高于对照组,白介素-6、C反应蛋白、肿瘤坏死因子-α水平均低于对照组,组间差异有统计学意义(P﹤0.05).结论在新生儿败血症中,人免疫球蛋白结合美罗培南治疗能够加快患者的临床症状改善,减轻炎症反应,调节免疫指标.

Objective Exploring the effect of human immunoglobulin combined with meropenem therapy on neonatal sepsis.Methods Selecting 60 cases of neonatal sepsis admitted to our hospital from August 2022 to August 2023 as the research subjects,divided into a control group and an observation group using a random number table method,with 30 cases in each group.The control group received treatment with meropenem,the observation group treated with human immunoglobulin combined with meropenem,both groups received continuous treatment for 10 days.The immune function indicators,clinical efficacy,time to symptom improvement,and inflammatory factor levels were compared between the two groups.Results After treatment,the total clinical effective rate of the observation group was higher than that of the control group,the difference between groups was statistically significant(P﹤0.05);the improvement time of body temperature,rejection of milk,neurological symptoms,as well as the time for blood culture to turn negative and hospital stay in the observation group were shorter than those in the control group,the differences between groups were statistically significant(P﹤0.05);The levels of immunoglobulin A,immunoglobulin G,and immunoglobulin M in the observation group were all higher than those in the control group,the levels of interleukin-6,C-reactive protein,and tumor necrosis factor-αwere also higher than those in the observation group,the differences between groups were statistically significant(P﹤0.05).Conclusion In neonatal sepsis,human immunoglobulin combined with meropenem treatment can accelerate the improvement of clinical symptoms,reduce inflammation,and regulate immune indicators.