清胃愈疡汤辅助奥美拉唑治疗消化道溃疡并发上消化道出血的有效性及安全性分析

Efficacy and Safety Analysis of Qingwei Yuyang Decoction Combined with Omeprazole in the Treatment of Upper Gastrointestinal Bleeding Caused by Peptic Ulcers

目的探讨清胃愈疡汤辅助奥美拉唑治疗消化道溃疡(PU)并发上消化道出血的临床效果.方法选取2022年1月—2023年6月同济大学附属东方医院胶州医院收治的82例PU并发上消化道出血患者为研究对象,按随机数字表法将其分为对照组及观察组,每组41例.对照组采用奥美拉唑治疗,观察组在此基础上采用清胃愈疡汤治疗,均持续治疗8周.比较两组患者的临床疗效、疾病症状改善时间、血红蛋白、胃液pH值、炎症水平、临床症状积分及安全性.结果观察组的治疗总有效率为95.12%,高于对照组的80.49%,差异有统计学意义(P﹤0.05).观察组的止血、大便转黄、潜血转阴时间均短于对照组,组间差异有统计学意义(P﹤0.05).治疗后,观察组的血红蛋白水平、胃液pH值均高于对照组,组间差异有统计学意义(P﹤0.05);观察组的上腹部疼痛、胃部灼热、烧心反酸、恶心呕吐积分均低于对照组,组间差异有统计学意义(P﹤0.05).两组的安全性比较,差异无统计学意义(P﹥0.05).结论清胃愈疡汤辅助奥美拉唑可提高PU并发上消化道出血的治疗效果,加快疾病症状消失,安全可靠.

Objective To investigate the clinical effect of Qingwei Yuyang Decoction combined with omeprazole in the treatment of upper gastrointestinal bleeding in patients with peptic ulcers(PU).Methods 82 patients with PU complicated with upper gastrointestinal hemorrhage admitted to Jiaozhou Hospital,Dongfang Hospital Affiliated to Tongji University from January 2022 to June 2023 were selected as the study objects and were divided into a control group and an observation group according to random number table method,with 41 cases in each group.The control group was treated with omeprazole,and the observation group was treated with Qingwei Yuyang Decoction on this basis.Both groups were treated for 8 weeks.The clinical efficacy,improvement time of disease symptoms,hemoglobin,pH value of gastric juice,inflammation levels,clinical symptom scores and safety of the two groups were compared.Results The total effective rate of the observation group was 95.12%,which was higher than 80.49%of the control group,the difference was statistically significant(P﹤0.05).The time of hemostasis,stool turning yellow and occult blood turning negative in the observation group were shorter than those in the control group,and the differences between the groups were statistically significant(P﹤0.05).After treatment,the hemoglobin level and pH value of gastric juice in the observation group were higher than those in the control group,and the differences between the groups were statistically significant(P﹤0.05);the scores of epigastric pain,stomach burn,heartburn reflux,nausea and vomiting in the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P﹤0.05).There was no significant difference in safety between the two groups(P﹥0.05).Conclusion Qingwei Yuyang Decoction combined with omeprazole can improve the therapeutic effect of PU complicated with upper gastrointestinal hemorrhage,accelerate the disappearance of disease symptoms,and is safe and reliable.