经皮穿刺微球囊压迫术与微血管减压术治疗三叉神经痛的效果及安全性比较

Comparison of the Efficacy and Safety of Percutaneous Balloon Compression and Microvascular Decompression in the Treatment of Trigeminal Neuralgia

目的探讨三叉神经痛(TN)患者行经皮穿刺微球囊压迫术(PMC)与微血管减压术(MVD)的疗效。方法选取我院2020年6月—2023年6月收治的86例TN患者为研究对象,按随机数字表法分为对照组与观察组,各43例。对照组行MVD治疗,观察组行PMC治疗。比较两组患者的临床疗效、炎症水平、应激反应指标、生活质量及并发症发生情况。结果观察组治疗总有效率为95.35%,高于对照组的81.40%,差异有统计学意义(P<0.05)。术后,观察组白细胞介素-1β、C反应蛋白、肿瘤坏死因子-α水平均低于对照组,组间差异有统计学意义(P<0.05);观察组丙二醛低于对照组,超氧化物歧化酶、谷胱甘肽过氧化物酶均高于对照组,组间差异有统计学意义(P<0.05);观察组世界卫生组织生活质量测定量表简表各领域评分均高于对照组,并发症发生率高于对照组,组间差异有统计学意义(P<0.05)。结论PMC治疗TN效果优于MVD,可减轻机体炎症及氧化损伤,利于改善患者术后生活质量,但并发症风险高。

Objective To investigate the clinical effects of percutaneous microballoon compression(PMC)and microvascular decompression(MVD)in the treatment of trigeminal neuralgia.Methods 86 patients with trigeminal neuralgia admitted to our hospital from June 2020 to June 2023 were selected as the study objects,and were divided into a control group and an observation group according to random number table method,with 43 cases in each group.The control group received MVD treatment,and the observation group received PMC treatment.The clinical efficacy,inflammation level,stress response index,quality of life and complications were compared between the two groups.Results The total effective rate of the observation group was 95.35%,higher than 81.40%of the control group,and the difference was statistically significant(P<0.05).After operation,the levels of interleukin-1β,C-reactive protein and tumor necrosis factor-α in observation group were lower than those in control group,with statistical significance(P<0.05);the malondialdehyde of observation group was lower than that of control group,and the superoxide dismutase and glutathione peroxidase of observation group were higher than those of control group,with statistical significance(P<0.05);the World Health Organization Quality of Life-Brief scores in the observation group were higher than those in the control group,and the incidence of complications was higher,with statistical significance(P<0.05).Conclusion PMC is more effective than MVD in the treatment of trigeminal neuralgia,which can reduce inflammation and oxidative damage of the body and improve the postoperative quality of life of patients,but the risk of complications is high.