莫西沙星结合康复训练对老年肺部感染患者症状改善、呼吸功能及炎性因子的影响

The Effect of Moxifloxacin Combined with Rehabilitation Training on Symptom Improvement,Respiratory Function and Inflammatory Factors in Elderly Patients with Pulmonary Infection

目的探讨莫西沙星结合康复训练对老年肺部感染患者症状改善、呼吸功能及炎性因子的影响。方法选择2020年4月—2023年4月本院收治的80例老年肺部感染患者为研究对象,根据1∶1随机掷硬币原则分为观察组和对照组,每组40例。对照组采用头孢哌酮舒巴坦治疗,观察组在对照组基础上采用莫西沙星结合康复训练干预,两组都治疗观察14 d,观察两组患者的症状改善、呼吸功能及炎性因子表达变化情况。结果治疗后,观察组的总有效率为97.50%,高于对照组的82.50%,组间差异有统计学意义(P<0.05)。观察组的退热时间、止咳时间、气促消失时间、肺部啰音消失时间均短于对照组,组间差异有统计学意义(P<0.05)。治疗后,观察组的血清C反应蛋白、肿瘤坏死因子-α水平均低于对照组,组间差异有统计学意义(P<0.05)。治疗后,观察组的第1秒用力呼气容积、用力肺活量比值和呼气峰流速占预测值百分比均大于对照组,组间差异有统计学意义(P<0.05)。结论莫西沙星结合康复训练在老年肺部感染患者的应用能促进症状改善,也可改善患者的呼吸功能,抑制炎性因子的表达。

Objective To explore and analysis the effects of moxifloxacin combined with rehabilitation training on symptom improvement,respiratory function,and inflammatory factors in elderly patients with pulmonary infection.Methods Selecting 80 elderly patients with pulmonary infections admitted to our hospital from April 2020 to April 2023 as the research subjects,divide into an observation group and a control group based on the 1:1 random coin toss principle,with 40 cases in each group.The control group was treated with cefoperazone sulbactam,the observation group received moxifloxacin combined with rehabilitation training intervention on the basis of the control group,and both groups were treated and observed for 14 days,observing the improvement of symptoms,respiratory function,and changes in inflammatory factor expression in two groups of patients.Results After treatment,the total effective rate of the observation group was 97.50%,higher than 82.50%of the control group,the difference between groups was statistically significant(P<0.05).The observation group had shorter fever relief time,cough relief time,disappearance time of shortness of breath,and disappearance time of lung rales compared to the control group,the differences between groups were statistically significant(P<0.05).After treatment,serum C-reactive protein and tumor necrosis factor-α in the observation group Level lower than the control group,the difference between groups is statistically significant(P<0.05).After treatment,the first second forced expiratory volume,forced vital capacity ratio,and peak expiratory flow rate as a percentage of predicted values in the observation group were greater than those in the control group,the difference between groups is statistically significant(P<0.05).Conclusion The application of moxifloxacin combined with rehabilitation training in elderly patients with pulmonary infection can promote symptom improvement,it can also improve the patient's respiratory function,inhibiting the expression of inflammatory factors.