小青龙颗粒辅助沙丁胺醇治疗支气管哮喘急性发作的效果

Effect of Xiaoqinglong Granules Assisted with Salbutamol in the Treatment of Acute Attack of Bronchial Asthma

目的观察支气管哮喘急性发作患者采用沙丁胺醇联合小青龙颗粒治疗的效果。方法选取2022年5月-2023年5月济阳区中医医院收治的86例支气管哮喘急性发作患者为研究对象,按随机数表法将其分为对照组及联合组。对照组采用沙丁胺醇治疗,联合组采用沙丁胺醇联合小青龙颗粒治疗。对比两组患者的哮喘控制优良率、症状缓解时间、肺功能、炎症水平及不良反应发生情况。结果联合组的哮喘控制优良率为93.02%,高于对照组的74.42%,差异有统计学意义(P<0.05)。联合组的呼吸困难减轻时间、咳嗽缓解时间、气短缓解时间、哮鸣音缓解时间分别为(2.26±0.64)d、(4.47±1.13)d、(2.37±0.58)d、(4.75±0.55)d,均短于对照组的(4.45±0.63)d、(5.94±1.08)d、(4.26±0.49)d、(6.11±0.52)d,组间差异有统计学意义(P<0.05)。治疗后,联合组的峰值呼气流速、最大通气量、第1秒用力呼气容积分别为(6.34±0.39)L/s、(60.38±5.09)L/min、(2.23±0.26)L,均大于对照组的(5.15±0.35)L/s、(50.92±6.78)L/min、(1.78±0.19)L,组间差异有统计学意义(P<0.05)。治疗后,联合组的中性粒细胞计数、白细胞计数、白细胞介素-6水平分别为(3.14±0.68)×10^(9)/L、(5.08±0.54)×10^(9)/L、(28.78±5.78)ng/L,均低于对照组的(3.95±0.62)×10^(9)/L、(6.22±0.56)×10^(9)/L、(35.56±6.04)ng/L,组间差异有统计学意义(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论支气管哮喘急性发作患者采用沙丁胺醇联合小青龙颗粒治疗,能加快症状缓解时间,改善肺功能,降低炎症水平,提升哮喘控制效果。

Objective To observe the effect of salbutamol combined with Xiaoqinglong Granule in the treatment of patients with acute attack of bronchial asthma.Methods 86 patients with acute attack of bronchial asthma admitted to Jiyang District Hospital of Traditional Chinese Medicine from May 2022 to May 2023 were selected as the study objects and were divided into a control group and a combination group according to random number table method.The control group was treated with salbutamol,and the combination group was treated with salbutamol combined with Xiaoqinglong Granule.The excellent and good rate of asthma control,symptom remission time,lung function,inflammation levels and occurrence of adverse reactions were compared between the two groups.Results The excellent and good rate of asthma control in the combination group was 93.02%,which was higher than 74.42%in the control group,the difference was statistically significant(P<0.05).The relief time of dyspnea,cough,shortness of breath and wheezing in the combined group were(2.26±0.64)d,(4.47±1.13)d,(2.37±0.58)d and(4.75±0.55)d,respectively,which were shorter than(4.45±0.63)d,(5.94±1.08)d,(4.26±0.49)d and(6.11±0.52)d in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the peak expiratory flow rate,maximal voluntary ventilation and forced expiratory volume in one second of the combined group were(6.34±0.39)L/s,(60.38±5.09)L/min and(2.23±0.26)L,respectively,which were greater than(5.15±0.35)L/s,(50.92±6.78)L/min,(1.78±0.19)L of the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the levels of neutrophil count,white blood cell count and interleukin-6 in the combined group were(3.14±0.68)×10^(9)/L,(5.08±0.54)×10^(9)/L,and(28.78±5.78)ng/L,respectively,which were lower than(3.95±0.62)×10^(9)/L,(6.22±0.56)×10^(9)/L,(35.56±6.04)ng/L in the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The treatment of salbutamol combined with Xiaoqinglong Granules in patients with acute attack of bronchial asthma can accelerate the time of symptom relief,improve lung function,reduce the levels of inflammation,and enhance the effect of asthma control.