乌拉地尔强化降压治疗对高血压脑出血患者脑血肿体积、神经功能及血流动力学的影响

Effect of Uradil Intensive Hypotension Therapy on Brain Hematoma Volume,Neurological Function and Hemodynamics in Patients with Hypertensive Cerebral Hemorrhage

目的观察高血压脑出血患者采用乌拉地尔强化降压时对患者脑血肿体积、神经功能及血流动力学的影响。方法选取我院2021年10月—2023年6月收治的80例高血压脑出血患者为研究对象,采用随机数字表法将其分为对照组和研究组,各40例。对照组采用常规降压治疗,研究组采用乌拉地尔强化降压治疗。对比两组脑血肿体积、神经功能及脑血流动力学。结果治疗3 d后,两组血肿体积均较治疗前缩小,且研究组血肿体积小于对照组,差异有统计学意义(P<0.05)。治疗1周后,两组美国国立卫生院神经功能缺损评分标准(NHISS)评分均较治疗前下降,且研究组NHISS评分低于对照组,差异有统计学意义(P<0.05)。治疗3 d后,两组脑血流平均流速(Vm)、脑血管平均血流量(Qm)均较治疗前升高,外周阻力(PR)较治疗前下降,且研究组Vm、Qm均高于对照组,PR低于对照组,差异有统计学意义(P<0.05)。结论高血压脑出血患者采取乌拉地尔强化降压治疗利于缩减脑血肿体积,改善脑血流,加速患者术后神经功能康复进程。

Objective To observe the effects of urapidil on the volume,neurological function and hemodynamics of cerebral hematoma in patients with hypertensive intracerebral hemorrhage.Methods 80 patients with hypertensive cerebral hemorrhage admitted to our hospital from October 2021 to June 2023 were selected as the research subjects.They were divided into a control group and a study group using a random number table method,with 40 patients in each group.The control group received routine antihypertensive treatment,while the study group received intensified antihypertensive treatment with urapidil.Compare the volume,neurological function,and cerebral hemodynamics of two groups of cerebral hematoma.Results After 3 days of treatment,the hematoma volume in both groups decreased compared to before treatment,and the hematoma volume in the study group was smaller than that in the control group,with a statistically significant difference(P<0.05).After one week of treatment,the National Institutes of Health Neurological Impairment Scale(NIHSS)scores of both groups decreased compared to before treatment,and the NIHSS scores of the study group were lower than those of the control group,with a statistically significant difference(P<0.05).After 3 days of treatment,the average cerebral blood flow velocity(Vm)and average cerebrovascular blood flow(Qm)in both groups increased compared to before treatment,while peripheral resistance(PR)decreased compared to before treatment;moreover,the Vm and Qm in the study group were higher than those in the control group,while PR was lower than those in the control group,with statistically significant differences(P<0.05).Conclusion Intensive antihypertensive therapy with urapidil is beneficial for reducing the volume of cerebral hematoma,improving cerebral blood flow,and accelerating the process of postoperative neurological rehabilitation in patients with hypertensive intracerebral hemorrhage.