一次性电子输尿管软镜碎石术对≤2cm肾结石患者结石清除率及炎性因子水平的影响

The Effect of Disposable Electronic Ureteroscopic Lithotripsy on Stone Clearance Rate and Inflammatory Factors in Patients with≤2 cm Renal Stones

目的分析一次性电子输尿管软镜碎石术在≤2 cm肾结石患者中的应用效果。方法选取2021年4月—2023年4月我院收治的92例≤2 cm肾结石患者为研究对象,按随机数字表法将其分为对照组和观察组,各46例。对照组行微创经皮肾镜碎石术,观察组行一次性电子输尿管软镜碎石术,术后随访1个月。对比两组手术相关指标、炎性因子水平、应激反应、并发症发生情况。结果两组结石清除率相比,差异无统计学意义(P>0.05)。观察组术中出血量为(10.31±1.59)mL,少于对照组的(26.89±3.41)mL,手术时间为(67.21±4.68)min、住院时间为(4.18±0.63)d,均短于对照组的(75.65±6.71)min、(7.21±1.54)d,并发症发生率为4.35%,低于对照组的17.39%,组间差异有统计学意义(P<0.05)。术后,观察组C反应蛋白为(7.96±1.21)mg/L,白细胞计数为(11.25±1.67)×10^(9)/L,去甲肾上腺素为(370.51±27.35)pmol/L,皮质醇为(168.29±15.27)nmol/L,均低于对照组的(10.24±1.68)mg/L、(13.77±2.58)×10^(9)/L、(397.68±31.46)pmol/L、(197.45±18.69)nmol/L,组间差异有统计学意义(P<0.05)。结论一次性电子输尿管软镜碎石术用于≤2 cm肾结石患者治疗效果显著,创伤更小,对患者造成的炎症反应、应激反应更轻,且并发症少。

Objective To analyze the effectiveness of disposable electronic ureteroscopic lithotripsy in patients with≤2 cm renal stones.Methods 92 patients with≤2 cm kidney stones admitted to the hospital from April 2021 to April 2023 were selected as the study subjects and they were randomly divided into a control group and an observation group,with 46 patients in each group.The control group underwent minimally invasive percutaneous nephrolithotripsy,while the observation group underwent one-time electronic ureteroscopic soft lithotripsy.The postoperative follow-up was 1 month.Compare the surgical related indicators,inflammatory factor levels,stress response,and complications between the two groups.Results There was no statistically significant difference in stone clearance rate between the two groups(P>0.05).The intraoperative bleeding volume in the observation group was(10.31±1.59)mL,which was less than the control group's(26.89±3.41)mL;the surgical time was(67.21±4.68)min,and the hospital stay was(4.18±0.63)d,which were shorter than(75.65±6.71)min and(7.21±1.54)d of the control group;the incidence of complications was 4.35%,which was lower than 17.39%of the control group,with a statistical difference(P<0.05).After surgery,the C-reactive protein,white blood cell count,norepinephrine,cortisol in the observation group were(7.96±1.21)mg/L,(11.25±1.67)×10^(9)/L,(370.51±27.35)pmol/L,(168.29±15.27)nmol/L,respectively,lower than the control group's(10.24±1.68)mg/L,(13.77±2.58)×10^(9)/L,(397.68±31.46)pmol/L,(197.45±18.69)nmol/L,with statistically significant differences(P<0.05).Conclusion Disposable electronic ureteroscopic lithotripsy is effective in the treatment of patients with≤2 cm renal stones,with less trauma,less inflammatory and stress reactions,and fewer complications.