左卡尼汀辅助高通量血液透析治疗尿毒症的效果分析

Effect of L-Carnitine Assisted High-Throughput Hemodialysis on Uremia and Its Influence on Microinflammatory Indexes in Patients

目的探讨左卡尼汀辅助高通量血液透析治疗尿毒症的疗效.方法选取2022年1-12月该院收治的90例尿毒症患者为研究对象,按照随机数字表法将其分为对照组和观察组.对照组(n=45)采用高通量血液透析,观察组(n=45)于对照组治疗措施基础上加用左卡尼汀.对比两组血常规指标、微炎症指标的变化情况.结果观察组的血红蛋白水平(86.02±15.33)g/L、红细胞计数水平(5.31±0.26)×10^(12)/L、红细胞比容水平(0.32±0.09)%高于对照组的(77.31±14.26)g/L、(4.10±0.20)×10^(12)/L、(0.21±0.07)%,观察组的肿瘤坏死因子-α水平(21.09±0.98)mg/L、超敏C-反应蛋白水平(5.82±0.71)mg/L、白细胞介素-6水平(14.39±1.38)ng/mL低于对照组的(23.62±1.33)mg/L、(6.94±1.21)mg/L、(17.62±1.76)ng/mL,组间差异有统计学意义(P<0.05).结论左卡尼汀辅助高通量血液透析治疗尿毒症可减轻患者机体炎症反应、调节血常规指标.

Objective To study the efficacy of levocarnitine-assisted high-throughput hemodialysis in uremia.Methods 90 uremia patients admitted to the hospital from January 2022 to December 2022 were selected as the study subjects and divided into a control group and an observation group according to the random number table method.The control group(n=45)received high-throughput hemodialysis,and the observation group(n=45)added levocarnitine on this basis.The changes of blood routine indexes and microinflammatory indexes were compared between the two groups.Results The levels of hemoglobin(86.02±15.33)g/L,red blood cell count(5.31±0.26)×10^(12)/L,erythrocyte specific volume(0.32±0.09)%in observation group were higher than(77.31±14.26)g/L,(4.10±0.20)×10^(12)/L,(0.21±0.07)%in the control group;the levels of tumor necrosis factor-α(21.09±0.98)mg/L,hypersensitive C-reactive protein(5.82±0.71)mg/L and interleukin-6(14.39±1.38)ng/mL in the observation group were lower than(23.62±1.33)mg/L,(6.94±1.21)mg/L,(17.62±1.76)ng/mL in the control group,and the differences between the groups were statistically significant(P<0.05).Conclusion L-carnitine assisted highthroughput hemodialysis in the treatment of uremia can reduce the inflammatory response of patients and regulate blood routine indexes.