帕罗西汀联合认知行为治疗对伴焦虑的抑郁症患者负性情绪及日常生活能力的影响

Effects of Paroxetine Combined with Cognitive Behavioral Therapy on Negative Emotions and Activities of Daily Living in Depression Patients with Anxiety

目的探讨帕罗西汀联合认知行为治疗对伴焦虑的抑郁症患者负性情绪及日常生活能力的影响.方法回顾性选取2021年7月—2022年7月于我院接受治疗的80例伴焦虑的抑郁症患者为研究对象.根据患者选用治疗方法不同将其分为对照组和观察组,对照组接受帕罗西汀治疗,观察组接受帕罗西汀联合认知行为治疗.比较两组焦虑、抑郁情况、精神状况与睡眠质量、日常生活能力和生活质量.结果治疗后,观察组SAS、SDS评分为(40.02±2.43)分、(45.36±4.17)分,均低于对照组的(54.54±3.54)分、(51.37±4.38)分,组间差异有统计学意义(P<0.05).治疗后,观察组MMSE评分为(21.11±4.23)分,高于对照组的(17.11±4.24)分,PSQI评分为(5.97±1.52)分,低于对照组的(8.78±2.23)分,组间差异有统计学意义(P<0.05).治疗后,观察组MBI评分、WHOQOL-BREF维度均分为(53.02±4.43)分、(96.26±7.37)分,均高于对照组的(45.54±7.54)分、(81.62±6.73)分,组间差异有统计学意义(P<0.05).结论帕罗西汀联合认知行为治疗可减轻伴焦虑的抑郁症患者负性情绪、改善患者精神状况与睡眠质量、提高患者日常生活能力及生活质量水平.

Objective To investigate the effect of Paroxetine combined with cognitive behavioral therapy on negative emotions and activities of daily living of depression patients with anxiety.Methods 80 patients with depression with anxiety who received treatment in our hospital from July 2021 to July 2022 were retrospectively selected and divided into a control group and an observation group according to treatment methods.The control group was treated with paroxetine,and the observation group was treated with paroxetine combined with cognitive behavioral therapy.Anxiety,depression,mental status and sleep quality,daily living ability and quality of life were compared between the two groups.Results After treatment,the SAS and SDS scores of the observation group were(40.02±2.43)points and(45.36±4.17)points,which were lower than(54.54±3.54)points and(51.37±4.38)points of the control group,and the differences were statistically significant between the two groups(P<0.05).After treatment,the MMSE score of the observation group was(21.11±4.23)points,which was higher than(17.11±4.24)points of the control group,and the PSQI score was(5.97±1.52)points,which was lower than(8.78±2.23)points of the control group,and the differences were statistically significant between the two groups(P<0.05).After treatment,the MBI and WHOQOL-BREF dimensions of the observation group were(53.02±4.43)points and(96.26±7.37)points,which were higher than(45.54±7.54)points and(81.62±6.73)points of the control group,and the differences were statistically significant between the two group(P<0.05).Conclusion Paroxetine combined with cognitive behavioral therapy has a significant effect on depression patients with anxiety,which can improve negative emotions,neurological function and sleep quality,daily life ability and quality of life.