小檗碱与美沙拉嗪联合治疗溃疡性结肠炎的临床疗效

Clinical Efficacy of Berberine Combined with Mesalazine in the Treatment of Ulcerative Colitis

目的探讨小檗碱联合美沙拉嗪治疗溃疡性结肠炎的临床疗效.方法选择2022年1月—2023年3月于我院治疗的153例溃疡性结肠炎患者为研究对象,以随机数字表法将患者分为对照组与观察组.对照组(n=77)口服美沙拉嗪治疗,观察组(n=76)在对照组基础上采取口服小檗碱治疗,治疗1个月后观察用药效果.比较两组临床疗效、治疗前后的疾病活动度及不良反应发生情况.结果观察组临床总有效率93.42%高于对照组的81.81%,差异有统计学意义(P<0.05).治疗前,两组患者的疾病活动度比较,差异无统计学意义(P>0.05).治疗后,两组患者溃疡性结肠炎活动指数的腹泻次数、医师评价、内镜检查、便血程度各维度分值均较治疗前下降,且观察组低于对照组,差异有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论采取小檗碱联合美沙拉嗪治疗溃疡性结肠炎的效果显著,可明显缓解临床症状,降低疾病活动度,且用药安全性良好.

Objective To explore the clinical efficacy of berberine combined with mesalazine in the treatment of ulcerative colitis and its impact on disease activity in patients.Methods 153 patients with ulcerative colitis who came to our hospital for treatment from January 2022 to March 2023 were selected and divided into a control group and an observation group using a random number table method.The control group(n=77)received oral administration of mesalazine,while the observation group(n=76)received oral administration of berberine on the basis of the control group.After one month of treatment,the medication effect was observed.Compare the clinical efficacy,disease activity before and after treatment,and adverse reactions between the two groups.Results The total clinical effective rate of the observation group 93.42%was higher than 81.81%of the control group,with a statistically significant difference(P<0.05).Before treatment,there was no statistically significant difference in disease activity between the two groups before treatment(P>0.05).After treatment,the scores of diarrhea frequency,physician evaluation,endoscopic examination,and degree of bloody stool in the two groups of ulcerative colitis activity index decreased,and the observation group was lower than the control group,with a statistically significant difference(P<0.05).There was no statistically significant difference in adverse reactions between the two groups(P>0.05).Conclusion The combination of berberine and mesalazine has a significant effect on the treatment of ulcerative colitis,which can significantly alleviate clinical symptoms,reduce disease activity,and have good medication safety.