双歧杆菌三联活菌联合熊去氧胆酸对乙肝肝硬化患者肠道屏障功能及血清内毒素的影响

Effects of Bifidobacterium Triple Viable Bacteria Combined with Ursodeoxycholic Acid on Intestinal Barrier Function and Serum Endotoxins in Patients with hepatitis B Cirrhosis

目的探讨双歧杆菌三联活菌联合熊去氧胆酸在乙肝肝硬化患者中的应用效果。方法选取2020年5月—2022年6月烟台市福山区人民医院收治的86例乙肝肝硬化患者为研究对象,按随机数字表法分为两组,每组43例。对照组采用熊去氧胆酸治疗,观察组在此基础上采用双歧杆菌三联活菌治疗,均持续1个月。对比两组患者的临床疗效、肠道屏障功能、血清内毒素、炎症因子、肝功能指标及不良反应发生情况。结果观察组的治疗总有效率为95.35%,高于对照组的81.40%,差异有统计学意义(P<0.05)。治疗后,观察组的血浆D-乳酸、二胺氧化酶、血清内毒素、白细胞介素-6、白细胞介素-1β、肿瘤坏死因子-α、谷草转氨酶、谷丙转氨酶水平均低于对照组,组间差异有统计学意义(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论乙肝肝硬化患者采用双歧杆菌三联活菌联合熊去氧胆酸治疗的效果显著,能改善肠道屏障功能,调节血清内毒素水平,减轻炎症反应,促进肝功能恢复。

Objective To investigate the application effect of bifidobacteria triple viable bacteria combined with ursodeoxycholic acid in patients with hepatitis B cirrhosis.Methods 86 patients with hepatitis B cirrhosis admitted to Yntai Fushan District people’s Hospital from May 2020 to June 2022 were selected as the research objects and were divided into two groups according to random number table method,with 43 cases in each group.The control group was treated with ursodeoxycholic acid,and the observation group was treated with bifidobacterium triple viable bacteria on this basis.Both groups lasted for 1 month.The clinical efficacy,intestinal barrier function,serum endotoxin,inflammatory factors,liver function indexes and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.35%,which was higher than 81.40%of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of plasma D-lactic acid,diamine oxidase,serum endotoxin,interleukin-6,interleukin-1β,tumor necrosis factor-α,aspartate aminotransferase and alanine aminotransferase in the observation group were lower than those in the control group,the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The bifidobacterium triple viable bacteria combined with ursodeoxycholic acid can improve intestinal barrier function,regulate serum endotoxin level,reduce inflammation and promote liver function recovery in patients with hepatitis B cirrhosis.