补肾活血汤联合穴位电针刺激对脊柱骨折合并脊髓损伤患者神经营养因子的影响

Effect of Bushen Huoxue Decoction Combined with Acupoint Electroacupuncture on Neurotrophic Factors in Patients with Spinal Fracture and Spinal Cord Injury

目的探讨补肾活血汤联合穴位电针刺激对脊柱骨折合并脊髓损伤患者神经营养因子的影响.方法选取2021年10月—2022年10月安徽中医药大学附属太和中医院收治的60例脊柱骨折合并脊髓损伤患者为研究对象,随机分为观察组(n=30)与对照组(n=30).对照组使用穴位电针刺激治疗,观察组使用补肾活血汤联合穴位电针刺激治疗,对比两组的神经营养因子、诱发电位波幅、神经功能.结果治疗8周后,观察组血清脑源性神经生长因子水平(4.89±0.68)ng/mL、神经营养素-3水平(28.73±3.03)ng/mL、神经生长因子水平(144.44±17.75)pg/mL水平均高于对照组的(4.14±0.65)ng/mL、(25.66±2.97)ng/mL、(132.82±15.05)pg/mL,组间差异有统计学意义(P<0.05);观察组运动诱发电位波幅(1.73±0.31)μV、体感诱发电位波幅(1.91±0.27)μV均大于对照组的(1.35±0.29)μV、(1.64±0.32)μV,组间差异有统计学意义(P<0.05);观察组美国脊柱损伤协会神经功能评分中触觉评分(85.47±8.89)分、痛觉评分(77.97±8.89)分、运动觉评分(75.44±7.67)分均高于对照组的(78.08±7.98)分、(69.43±9.37)分、(68.76±7.52)分,组间差异有统计学意义(P<0.05).结论补肾活血汤联合穴位电针刺激治疗脊柱骨折合并脊髓损伤患者能增加神经营养因子,增强脊髓传导,促进神经功能恢复.

Objective To explore the effect of Bushen Huoxue Decoction combined with acupoint electroacupuncture on neurotrophic factors in patients with spinal fracture and spinal cord injury.Methods 60 patients with spinal fracture combined with spinal cord injury who were admitted to Taihe Hospital of Traditional Chinese Medicine Affiliated to Anhui University of Chinese Medicine from October 2021 to October 2022 were selected as the research objects and randomly divided into the observation group(n=30)and the control group(n=30).The control group was treated with acupoint electroacupuncture,and the observation group was treated with Bushen Huoxue Decoction combined with acupoint electroacupuncture.The neurotrophic factors,evoked potential amplitude and nerve function of the two groups were compared.Results After 8 weeks of treatment,the serum levels of brain-derived nerve growth factor(4.89±0.68)ng/mL,neurotrophin-3(28.73±3.03)ng/mL,nerve growth factor(144.44±17.75)pg/mL in the observation group were higher than(4.14±0.65)ng/mL,(25.66±2.97)ng/mL,(132.82±15.05)pg/mL in the control group,with a statistically significant difference between the two groups(P<0.05);the amplitude of motor evoked potential in the observation group(1.73±0.31)μV.Amplitude of somatosensory evoked potential(1.91±0.27)μV were greater than(1.35±0.29)μV、(1.64±0.32)μV of the control group.The difference was statistically significant between the two groups(P<0.05);the tactile score(85.47±8.89)points,pain score(77.97±8.89)points and kinesthetic score(75.44±7.67)points of the American Spinal Injury Association in the observation group were higher than(78.08±7.98)points,(69.43±9.37)points and(68.76±7.52)points of the control group,with statistically significant differences between the two groups(P<0.05).Conclusion Bushen Huoxue Decoction combined with acupoint electroacupuncture can increase neurotrophic factors,enhance spinal cord conduction and promote the recovery of nerve function in patients with spinal fracture and spinal cord injury.