通脑复原汤辅助治疗对脑梗死恢复期患者血液流变学及血管内皮功能的影响

Effect of Tongnao Fuyuan Decoction on Hemorheology and Vascular Endothelial Function in Patients with Cerebral Infarction during Recovery Stage

目的探讨通脑复原汤辅助治疗对脑梗死恢复期患者血液流变学及血管内皮功能的影响。方法选取2021年10月—2022年10月本院收治的92例脑梗死恢复期患者为研究对象,随机分为两组。对照组(n=46)采用常规治疗,观察组(n=46)在此基础上采用通脑复原汤辅助治疗。对比两组患者的血液流变学指标、血管内皮功能及神经功能。结果治疗4周后,观察组的全血黏度低切、全血黏度高切、红细胞压积、血浆黏度、纤维蛋白原水平分别为(8.89±0.89)mPa•s、(6.03±0.68)mPa•s、(37.32±3.11)%、(1.03±0.25)mPa•s、(2.56±0.41)g/L,均低于对照组,组间差异有统计学意义(P<0.05)。治疗4周后,观察组的血清血管内皮生长因子、一氧化氮水平分别为(475.41±50.13)ng/L、(48.14±4.29)μmol/L,均高于对照组,血管紧张素Ⅱ、血清内皮素水平分别为(15.89±1.78)μg/L、(57.47±6.26)pg/mL,均低于对照组,组间差异有统计学意义(P<0.05)。治疗4周后,观察组的美国国立卫生研究院卒中量表评分为(6.62±1.35)分,低于对照组,差异有统计学意义(P<0.05)。结论通脑复原汤辅助治疗可改善脑梗死恢复期患者的血液流变学指标及血管内皮功能,减轻其神经功能缺损,值得临床推广使用。

Objective To explore the effect of Tongnao Fuyuan Decoction on hemorheology and vascular endothelial function in patients with cerebral infarction during the recovery period.Methods 92 patients with cerebral infarction in recovery stage admitted to the hospital from October 2021 to October 2022 were selected as the research objects and randomly divided into two groups.The control group(n=46)received conventional treatment,and the observation group(n=46)received adjuvant treatment with Tongnao Fuyuan Decoction.The hemorheology indexes,vascular endothelial function and nerve function of the two groups were compared.Results After 4 weeks of treatment,the whole blood viscosity low shear,whole blood viscosity high shear,hematocrit,plasma viscosity and fibrinogen levels in the observation group were(8.89±0.89)mPa•s,(6.03±0.68)mPa•s,(37.32±3.11)%,(1.03±0.25)mPa•s,(2.56±0.41)g/L,respectively,which were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).After 4 weeks of treatment,the serum vascular endothelial growth factor and nitric oxide levels in the observation group were(475.41±50.13)ng/L and(48.14±4.29)μmol/L,respectively,which were higher than those in the control group,while the levels of angiotensinⅡand endothelin in serum were(15.89±1.78)μg/L and(57.47±6.26)pg/mL,respectively,which were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).After 4 weeks of treatment,the National Institutes of Health stroke scale score in the observation group was(6.62±1.35)points,which was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Tongnao Fuyuan Decoction can improve the hemorheology indexes and vascular endothelial function of cerebral infarction patients in the recovery stage,and alleviate the neurological function defect,which is worthy of clinical popularization.