依达拉奉右莰醇联合阿替普酶静脉溶栓对急性缺血性脑卒中患者神经功能的影响

Effect of Edaravondalcohol Combined with Alteplase Intravenous Thrombolysis on Neurological Function in Patients with Acute Ischemic Stroke

目的探究依达拉奉右莰醇联合阿替普酶(rt-PA)静脉溶栓对急性缺血性脑卒中患者神经功能的影响.方法选择2021年6月—2022年6月本院收治的49例急性缺血性脑卒中患者为研究对象,按照随机数字表法分为对照组(n=25)和观察组(n=24).对照组采用rt-PA静脉溶栓治疗,观察组在对照组基础上加用依达拉奉右莰醇,均持续治疗10 d.对比两组神经功能、临床疗效、氧化应激反应、生活能力、不良反应.结果观察组治疗总有效率95.83%较对照组的68.00%高,差异有统计学意义(P<0.05).两组治疗前美国国立卫生研究院卒中量表(NIHSS)评分、氧化应激反应指标水平、改良Barthel指数评定量表(MBI)评分对比,组间差异无统计学意义(P>0.05);观察组治疗后NIHSS评分(15.34±2.13)分、丙二醛水平(3.48±0.53)mmol/L均低于对照组,超氧化物歧化酶水平(98.25±12.57)U/mL、谷胱甘肽过氧化物酶水平(40.38±6.07)U/L、MBI评分(72.10±3.88)分均高于对照组,组间差异有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论依达拉奉右莰醇联合rt-PA静脉溶栓能够有效改善急性缺血性脑卒中患者神经功能,减轻氧化应激反应,提高生活能力,且安全可靠.

Objective To investigate the effect of edaravondalcohol combined with alteplase(rt-PA)intravenous thrombolysis on neurological function in patients with acute ischemic stroke.Methods 49 patients with acute ischemic stroke admitted to the hospital from June 2021 to June 2022 were selected as research objects,and were divided into a control group(n=25)and an observation group(n=24)according to random number table method.The control group was treated with rt-PA intravenous thrombolysis,and the observation group was treated with edaravondalcohol on the basis of the control group,with both interventions for 10 days.Neurological function,clinical efficacy,oxidative stress response,life ability and adverse reactions were compared between the two groups.Results The total effective rate of treatment 95.83%of the observation group was higher than 68.00%of the control group,and the difference was statistically significant(P<0.05).There were no significant differences in the National Institute of Health stroke scale(NIHSS)score,oxidative stress response indicators levels and modified Barthel index(MBI)score between the two groups before treatment(P>0.05);the NIHSS score(15.34±2.13)points and malondialdehyde level(3.48±0.53)mmol/L in the observation group after treatment were lower than those in the control group,superoxide dismutase level(98.25±12.57)U/mL and glutathione peroxidase level(40.38±6.07)U/L and the MBI score(72.10±3.88)points were higher than those in the control group,the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Edaravondalcohol combined with rt-PA intravenous thrombolysis can effectively improve neurological function,reduce oxidative stress response and improve life ability in patients with acute ischemic stroke,and it is safe and reliable.