布地奈德联合氨溴索对吸入性肺炎患儿氧合指数及炎症因子水平的影响

Effects of Budesonide Combined with Ambroxol on Oxygenation Index and Levels of Inflammatory Factors in Children with Aspiration Pneumonia

目的探究布地奈德联合氨溴索对吸入性肺炎患儿氧合指数及炎症因子水平的影响.方法选取2021年6月—2022年7月巨野县人民医院收治的68例吸入性肺炎患儿为研究对象,按随机数表法分成两组,每组34例.对照组采用氨溴索雾化治疗,观察组采用布地奈德联合氨溴索雾化治疗,两组均持续治疗7d.对比两组患儿的临床疗效、症状消失时间、氧合指数、炎症反应及不良反应发生情况.结果观察组的治疗总有效率为97.05%,高于对照组的76.47%,差异有统计学意义(P<0.05).治疗后,观察组的呼吸困难、口周紫绀、肺部啰音、口吐泡沫消失时间分别为(3.21±0.58)d、(2.83±0.42)d、(4.22±1.21)d、(3.04±0.49)d,均短于对照组,组间差异有统计学意义(P<0.05).治疗后,观察组的氧合指数为(378.43±16.44)mmHg,高于对照组,差异有统计学意义(P<0.05).治疗后,观察组的白细胞介素-6、超敏C反应蛋白、肿瘤坏死因子-α水平分别为(15.19±0.86)pg/mL、(22.56±6.47)ng/L、(23.31±6.33)ng/L,均低于对照组,组间差异有统计学意义(P<0.05).两组的不良反应发生率比较,差异无统计学意义(P>0.05).结论布地奈德联合氨溴索治疗新生儿吸入性肺炎的效果较佳,可缩短临床症状消失时间,改善患儿氧合指数,减轻其炎症反应,安全可靠.

Objective To investigate the effects of budesonide combined with ambroxol on oxygenation index and inflammatory factors levels in children with aspiration pneumonia.Methods 68 cases of children with aspiration pneumonia admitted to Juye County People's Hospital from June 2021 to July 2022 were selected as the research objects and were divided into two groups according to random number table method,with 34 cases in each group.The control group was treated with ambroxol atomization,and the observation group was treated with budesonide combined with ambroxol atomization.Both groups were treated for 7 days.The clinical efficacy,duration of symptom disappearance,oxygenation index,inflammatory reaction and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 97.05%,which was higher than 76.47%of the control group,the difference was statistically significant(P<0.05).After treatment,the disappearance time of dyspnea,perioral cyanosis,pulmonary rale and foaming in the observation group were(3.21±0.58)d,(2.83±0.42)d,(4.22±1.21)d and(3.04±0.49)d,respectively,which were shorter than those in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the oxygenation index of the observation group was(378.43±16.44)mmHg,higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of interleukin-6,hypersensitive C-reactive protein and tumor necrosis factor-αin the observation group were(15.19±0.86)pg/mL,(22.56±6.47)ng/L and(23.31±6.33)ng/L,respectively,which were lower than those in the control group,the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Budesonide combined with ambroxol is effective in the treatment of neonatal aspiration pneumonia,which can shorten the disappearance time of clinical symptoms,improve the oxygenation index and reduce the inflammatory response of children.It is safe and reliable.