氨溴索联合二羟丙茶碱对慢性支气管炎急性发作期患者血气分析及炎症反应的影响

Effect of Ambroxol Combined with Dihydroxypropyl Theophylline on Blood Gas Analysis and Inflammatory Reaction in Patients with Acute Attack Stage of Chronic Bronchitis

目的分析二羟丙茶碱与氨溴索联合应用于慢性支气管炎(CB)急性发作期患者中的临床效果.方法选取2020年12月—2022年9月该院收治的76例CB急性发作期患者为研究对象,按随机数字表法分为两组.对照组(n=38)接受氨溴索注射液治疗,观察组(n=38)在对照组基础上加用二羟丙茶碱注射液治疗.两组均持续治疗7 d.对比两组临床症状消失时间、血气分析指标、炎性因子以及不良反应.结果治疗后,观察组肺啰音消失时间(3.31±0.79)d、胸闷消失时间(3.27±0.68)d、咳痰气急消失时间(3.16±0.77)d、咳嗽消失时间(3.51±0.98)d均短于对照组的(5.14±1.08)d、(5.26±0.74)d、(5.34±0.98)d、(5.64±1.05)d,组间差异有统计学意义(P<0.05).治疗前,两组血气分析指标及炎性因子对比,组间差异无统计学意义(P>0.05);治疗后,观察组动脉血二氧化碳分压(35.07±3.98)mmHg、白细胞介素-6(112.14±8.47)μg/L、肿瘤坏死因子-α(0.82±0.16)pg/L、C反应蛋白(5.12±2.28)mg/L均低于对照组的(48.25±3.44)mmHg、(128.07±9.44)μg/L、(1.31±0.24)pg/L、(7.08±2.36)mg/L,动脉血氧分压(85.36±10.54)mmHg、动脉血氧含量(8.97±1.14)mmol/L均高于对照的(74.29±10.11)mmHg、(8.12±1.03)mmol/L,组间差异有统计学意义(P<0.05).两组不良反应发生率对比,差异无统计学意义(P>0.05).结论二羟丙茶碱与氨溴索联合应用于CB急性发作期患者中的疗效确切,能够缩短临床症状消失时间,改善血气分析指标,减轻炎症反应,且安全性高.

Objective To analyze the clinical effect of the combination of dihydroxypropyl theophylline and ambroxol in patients with acute attack stage of chronic bronchitis(CB).Methods 76 patients with acute attack stage of CB admitted to the hospital from December 2020 to September 2022 were selected as the research objects,and divided into two groups according to random number table method.The control group(n=38)was treated with ambroxol injection,and the observation group(n=38)was treated with dihydroxypropyl theophylline injection on the basis of the control group.Both groups were treated continuously for 7 days.The absence time of clinical symptoms,blood gas analysis indexes,inflammatory factors and adverse reactions were compared between the two groups.Results After treatment,the disappearance time of pulmonary rales,chest tightness,cough and shortness of breath,spittoon in the observation group were(3.31±0.79)d,(3.27±0.68)d,(3.16±0.77)d,(3.51±0.98)d,respectively,which were shorter than(5.14±1.08)d,(5.26±0.74)d,(5.34±0.98)d and(5.64±1.05)d in the control group,and the differences between the groups were statistically significant(P<0.05).Before treatment,there were no significant differences in blood gas analysis indexes and inflammatory factors between the two groups(P>0.05);after treatment,the arterial blood partial pressure of carbon dioxide,interleukin-6,tumor necrosis factor-αand C-reactive protein in the observation group were(35.07±3.98)mmHg,(112.14±8.47)μg/L,(0.82±0.16)pg/L and(5.12±2.28)mg/L,respectively,which were lower than(48.25±3.44)mmHg,(128.07±9.44)μg/L,(1.31±0.24)pg/L and(7.08±2.36)mg/L in the control group,the arterial blood partial pressure of oxygen and arterial oxygen content of the observation group were(85.36±10.54)mmHg and(8.97±1.14)mmol/L,respectively,which were higher than(74.29±10.11)mmHg and(8.12±1.03)mmol/L of the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combined application of dihydroxypropyl theophylline and ambroxol in patients with acute attack stage of CB has definite efficacy,can shorten the time of disappearance of clinical symptoms,improve blood gas analysis indicators,reduce inflammation,and high safety.