奥美拉唑联合凝血酶对肝硬化合并上消化道出血患者止血效果及炎症反应的影响

Effect of Omeprazole Combined with Thrombin on Hemostasis and Inflammatory Reaction in Patients with Liver Cirrhosis Complicated with Upper Gastrointestinal Hemorrhage

目的探究奥美拉唑联合凝血酶对肝硬化合并上消化道出血患者止血效果及炎症反应的影响.方法选择本院2021年1月—2022年6月收治的67例肝硬化合并上消化道出血患者为研究对象,按照随机数字表法分为对照组(n=33)和观察组(n=34).对照组采用奥美拉唑治疗,观察组在对照组基础上联合凝血酶治疗,均持续治疗5d.比较两组止血效果、临床指标、炎症反应、安全性.结果观察组总有效率91.18%高于对照组的69.70%,止血时间(27.18±2.25)h、住院时间(5.23±1.02)d均短于对照组,输血量(286.48±12.27)mL少于对照组,组间差异有统计学意义(P<0.05).治疗前,两组各项炎症指标水平比较,组间差异无统计学意义(P>0.05);治疗后,观察组C反应蛋白(8.32±0.94)mg/L、降钙素原(0.27±0.03)ng/mL、白细胞介素-2(2.80±0.22)μg/mL均低于对照组,组间差异有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论在肝硬化合并上消化道出血患者中采用奥美拉唑联合凝血酶治疗,能够有效提高止血效果,减少输血量,缓解炎症反应,缩短治疗时间,且安全可靠.

Objective To investigate the effect of omeprazole combined with thrombin on hemostasis and inflammatory reaction in patients with liver cirrhosis complicated with upper gastrointestinal hemorrhage.Methods 67 patients with liver cirrhosis complicated with upper gastrointestinal hemorrhage admitted to the hospital from January 2021 to June 2022 were selected as the study objects,and were divided into a control group(n=33)and an observation group(n=34)according to random number table method.The control group was treated with omeprazole,and the observation group was treated with thrombin on the basis of the control group,and both groups were treated continuously for 5 days.The hemostatic effect,clinical indicators,inflammatory reaction and safety of the two groups were compared.Results The total effective rate of the observation group was 91.18%,which was higher than 69.70%of the control group,the hemostasis time and hospitalization time of the observation group were(27.18±2.25)h and(5.23±1.02)d,respectively,which were shorter than those of the control group,the blood transfusion volume was(286.48±12.27)mL,which was less than that of the control group,and the differences between the groups were statistically significant(P<0.05).Before treatment,there was no statistical significance in the levels of various inflammatory indicators between the two groups(P>0.05);after treatment,the levels of C-reactive protein,procalcitonin and interleukin-2 in the observation group were(8.32±0.94)mg/L,(0.27±0.03)ng/mL and(2.80±0.22)μg/mL,respectively,which were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of omeprazole and thrombin in the treatment of patients with liver cirrhosis complicated with upper gastrointestinal hemorrhage can effectively improve hemostatic effect,reduce the amount of blood transfusion,relieve inflammation,shorten the treatment time,and which is safe and reliable.