血管内介入栓塞术对脑动脉瘤患者围术期指标、氧化应激指标、神经功能及生活活动能力的影响

Effects of Intravascular Interventional Embolization on Perioperative Indexes,Oxidative Stress Indexes,Neurological Function and Activity of Life in Patients with Cerebral Aneurysm

目的探讨血管内介入栓塞术对脑动脉瘤患者围术期指标及氧化应激指标的影响.方法选取2019年7月—2022年7月德州市平原县第一人民医院收治的106例脑动脉瘤患者为研究对象,随机分为观察组(n=53)与对照组(n=53).观察组采用血管内介入栓塞术治疗,对照组采用开颅夹闭术治疗.对比两组患者的围术期指标、氧化应激指标、神经功能、生活活动能力及术后并发症发生情况.结果观察组的切口长度短于对照组,术中出血量少于对照组,手术及住院时间均短于对照组,组间差异有统计学意义(P<0.05).术后第14天,观察组的超氧化物歧化酶、谷胱甘肽过氧化物酶、过氧化氢酶水平均高于对照组,丙二醛水平低于对照组,组间差异有统计学意义(P<0.05).术后3个月,观察组的美国国立卫生研究院卒中量表评分低于对照组,改良版Barthel指数量表评分高于对照组,组间差异有统计学意义(P<0.05).观察组的术后并发症发生率为3.77%,低于对照组18.87%,差异有统计学意义(P<0.05).结论采用血管内介入栓塞术治疗脑动脉瘤患者,可调节其氧化应激反应,改善围术期指标及术后神经功能、生活活动能力,减少术后并发症的发生,值得临床推广使用.

Objective To investigate the effect of intravascular interventional embolization on perioperative indexes and oxidative stress indexes in patients with cerebral aneurysms.Methods 106 patients with cerebral aneurysm admitted to the First People's Hospital of Pingyuan County in Dezhou City from July 2019 to July 2022 were selected as the research objects and were randomly divided into the observation group(n=53)and the control group(n=53).The observation group was treated with intravascular interventional embolization,while the control group was treated with craniotomy.The perioperative indexes,oxidative stress indexes,neurological function,living activity ability and postoperative complications were compared between the two groups.Results The incision length in the observation group was shorter than that in the control group,the intraoperative blood loss was less than that of the control group,and the length of operation and hospital stay were shorter than those in the control group,the differences between the groups were statistically significant(P<0.05).On the 14th day after surgery,the levels of superoxide dismutase,glutathione peroxidase and catalase in the observation group were higher than those in the control group,but the level of malondialdehyde was lower than that in the control group,the differences between the groups were statistically significant(P<0.05).3 months after surgery,the score of the National Institutes of Health stroke scale in the observation group was lower than that in the control group,and the score of the modified Barthel index scale was higher than that in the control group,the differences between the groups were statistically significant(P<0.05).The incidence of postoperative complications in the observation group was 3.77%lower than 18.87%in the control group,and the difference was statistically significant(P<0.05).Conclusion Intravascular interventional embolization in the treatment of cerebral aneurysm patients can adjust the oxidative stress response,improve perioperative indexes,postoperative neurological function,life activity ability,reduce the occurrence of postoperative complications,and is worthy of clinical application.