艾司西酞普兰联合佐匹克隆对焦虑障碍伴失眠患者焦虑程度及睡眠质量的影响

Effect of Escitalopram Combined with Zopiclone on Degree of Anxiety and Sleep Quality in Patients with Anxiety Disorder and Insomnia

目的探讨艾司西酞普兰联合佐匹克隆对焦虑障碍伴失眠患者焦虑程度及睡眠质量的影响.方法选取2019年7月—2022年4月常熟市第一人民医院心理门诊接诊的66例焦虑障碍伴失眠患者为研究对象,以随机数表法分为两组.对照组(n=33)采用艾司西酞普兰治疗,观察组(n=33)在对照组基础上加用佐匹克隆治疗,均连续治疗3个月.比较两组焦虑程度、睡眠质量、生活质量、临床疗效以及不良反应.结果观察组治疗后汉密尔顿焦虑量表评分(4.33±0.79)分、睡眠障碍评定量表评分(5.25±0.81)分均低于对照组的(7.15±1.31)分、(8.62±1.13)分,健康调查简表中生理功能评分(82.21±4.33)分、身体疼痛评分(85.19±2.47)分、总体健康评分(86.15±2.26)分、社会功能评分(86.37±2.26)分、情感职能评分(87.35±2.42)分、精神健康评分(85.18±2.09)分、活力评分(87.19±2.16)分、健康变化评分(84.15±2.24)分均高于对照组,组间差异有统计学意义(P<0.05).观察组临床总有效率93.94%高于对照组的66.67%,差异有统计学意义(P<0.05).两组不良反应发生率对比,差异无统计学意义(P>0.05).结论焦虑障碍伴失眠患者采用艾司西酞普兰与佐匹克隆治疗的临床效果显著,能有效缓解患者的焦虑症状,改善睡眠质量,提升生活质量,且安全性高.

Objective To investigate the effect of escitalopram combined with zopiclone on degree of anxiety and sleep quality in patients with anxiety disorder and insomnia.Methods 66 patients with anxiety disorder and insomnia admitted to the psychological clinic of the Changshu First People's Hospital from July 2019 to April 2022 were selected as the research objects and divided into two groups by random number table method.The control group(n=33)was treated with escitalopram,and the observation group(n=33)was additionally treated with zopiclone on the basis of control group.Both groups were treated continuously for 3 months.The degree of anxiety,sleep quality,quality of life,clinical efficacy and adverse reactions were compared between the two groups.Results After treatment,the scores of Hamilton anxiety scale and sleep dysfunction rating scale of the observation group were(4.33±0.79)points and(5.25±0.81)points,respectively,which were lower than(7.15±1.31)points and(8.62±1.13)points of the control group,the scores of physiological function,physical pain,general health,social function,emotional function,mental health,vitality and health change in the MOS item short from health survey in the observation group were(82.21±4.33)points,(85.19±2.47)points,(86.15±2.26)points,(86.37±2.26)points,(87.35±2.42)points,(85.18±2.09)points,(87.19±2.16)points and(84.15±2.24)points,respectively,which were higher than those in the control group,and the differences between the groups were statistically significant(P<0.05).The total clinical effective rate of the observation group was 93.94%,which was higher than 66.67%of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Escitalopram combined with zopiclone has a significant clinical effect in the treatment of patients with anxiety disorder with insomnia,which can effectively improve patients'anxiety,sleep quality and life quality,and has high safety.