盐酸米诺环素软膏联合替硝唑对慢性牙周炎患者外周血Th17、Treg水平及临床症状的影响

Effects of Minocycline Hydrochloride Ointment Combined with Tinidazole on the Levels of Th17 and Treg in Peripheral Blood and Clinical Symptoms in Patients with Chronic Periodontitis

目的探讨联用盐酸米诺环素软膏及替硝唑在慢性牙周炎中的治疗效果.方法选取我院2020年5月—2022年5月收治的慢性牙周炎患者86例,按随机数字表法分为两组,每组43例.对照组采用替硝唑治疗,观察组加用盐酸米诺环素软膏治疗,均持续治疗4周.比较两组治疗效果及安全性.结果观察组总有效率为95.35%,高于对照组的81.40%,观察组治疗后Th17、Treg水平分别为(1.35±0.23)%、(4.03±0.75)%,均低于对照组的(1.69±0.25)%、(4.58±0.79)%,差异有统计学意义(P<0.05).治疗后,观察组的龈沟出血指数、菌斑指数、牙龈指数及牙周袋深度为(1.08±0.12)分、(0.96±0.12)分、(1.22±0.13)分、(1.62±0.23)mm,均低于对照组的(1.31±0.14)分、(1.22±0.15)分、(1.46±0.19)分、(1.95±0.26)mm,观察组的白细胞介素-6、超敏C反应蛋白及肿瘤坏死因子-α水平为(3.25±0.41)ng/mL、(6.25±1.02)mg/L、(3.15±0.38)ng/mL,均低于对照组的(4.05±0.58)ng/mL、(7.53±1.14)mg/L、(3.87±0.42)ng/mL,差异有统计学意义(P<0.05).两组不良反应相比,差异无统计学意义(P>0.05).结论联用盐酸米诺环素及替硝唑可提高慢性牙周炎患者疗效,改善牙周临床症状,纠正Th17、Treg水平异常,减轻炎症反应,安全可靠,值得临床推广使用.

Objective To investigate the clinical effect of minocycline hydrochloride ointment combined with tinidazole in the treatment of chronic periodontitis.Methods A total of 86 patients with chronic periodontitis admitted to our hospital from May 2020 to May 2022 were selected and were divided into two groups according to random number table method,with 43 cases in each group.The tinidazole was used in control group,the minocycline hydrochloride ointment was added to the observation group.Both groups were treated continuously for 4 weeks.The two groups'therapeutic effect and safety were compared.Results The observation group's total effective rate was 95.35%,higher than control group's 81.40%,the Th17 and Treg levels after treatment were(1.35±0.23)%and(4.03±0.75)%,respectively,lower than control group's(1.69±0.25)%and(4.58±0.79)%,and the differences between the groups were statistically significant(P<0.05).After treatment,the observation group's gingival creval bleeding index,plaque index,gingival index and periodontal pocket depth were(1.08±0.12)points,(0.96±0.12)points,(1.22±0.13)points and(1.62±0.23)mm,respectively,lower than control group's(1.31±0.14)points,(1.22±0.15)points,(1.46±0.19)points and(1.95±0.26)mm,and the differences between the groups were statistically significant(P<0.05).After treatment,the observation group's interleukin-6,hypersensitive C-reactive protein and tumor necrosis factor-αlevels were(3.25±0.41)ng/mL,(6.25±1.02)mg/L and(3.15±0.38)ng/mL,respectively,lower than control group's(4.05±0.58)ng/mL,(7.53±1.14)mg/L and(3.87±0.42)ng/mL,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in ADR between the two groups(P>0.05).Conclusion The combination of Minocycline hydrochloride and tinidazole can enhance the therapeutic effect of chronic periodontitis,improve periodontal clinical symptoms,correct abnormal Th17 and Treg levels,reduce inflammation,safe and reliable,worthy of clinical promotion.