阿卡波糖联合二甲双胍对2型糖尿病患者血糖控制及细胞免疫功能的影响

Effects of Acarbose Combined with Metformin on Blood Glucose Control and Cellular Immune Function in Patients with Type 2 Diabetes Mellitus

目的探讨阿卡波糖联合二甲双胍在2型糖尿病(T2DM)患者中的治疗效果.方法选取2020年5月—2022年2月我院收治的86例T2DM患者,按随机数字表法分为两组,每组43例.对照组采用二甲双胍治疗,观察组在此基础上采用阿卡波糖治疗.对比两组的临床疗效、血糖水平、细胞免疫功能及不良反应发生率.结果观察组的治疗总有效率为95.35%,高于对照组的81.40%,差异有统计学意义(P<0.05).治疗后,观察组的空腹血糖、餐后2 h血糖、糖化血红蛋白水平分别为(6.88±1.22)mmol/L、(8.03±1.80)mmol/L、(6.05±0.68)%,均低于对照组,组间差异有统计学意义(P<0.05).治疗后,观察组的CD3+、CD4+、CD4+/CD8+水平均高于对照组,CD8+水平低于对照组,组间差异有统计学意义(P<0.05).两组的不良反应发生率比较,差异无统计学意义(P>0.05).结论阿卡波糖联合二甲双胍能增强T2DM的治疗效果,降低患者血糖水平,改善其机体细胞免疫功能,安全性高.

Objective To investigate the therapeutic effect of acarbose combined with metformin in patients with type 2 diabetes mellitus(T2DM).Methods A total of 86 T2DM patients admitted to our hospital from May 2020 to February 2022 were selected and were divided into two groups according to random number table method,with 43 cases in each group.The control group was treated with metformin,and the observation group was treated with acarbose on this basis.The clinical efficacy,blood glucose level,cellular immune function and adverse reaction rate of the two groups were compared.Results The total effective rate of the observation group was 95.35%,which was higher than 81.40%of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of fasting blood glucose,2 h postprandial blood glucose and HbA1c in the observation group were(6.88±1.22)mmol/L,(8.03±1.80)mmol/L and(6.05±0.68)%,respectively,which were lower than those of the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the levels of CD3+,CD4+and CD4+/CD8+in the observation group were higher than those in the control group,and the level of CD8+was lower than that in the control group,the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Acarbose combined with metformin can enhance the therapeutic effect of T2DM,reduce the blood glucose level and improve the cellular immune function of patients with high safety.