奥氮平结合康复训练改善老年痴呆精神行为障碍患者认知功能的效果

Effect of Olanzapine Combined with Rehabilitation Training on Cognitive Function in Senile Dementia Patients with Mental and Behavioral Disorders

目的分析奥氮平结合康复训练改善老年痴呆精神行为障碍患者认知功能的效果.方法选取我院2019年1月—2022年2月收治的90例老年痴呆精神行为障碍患者为研究对象,根据随机数字表法分为两组.对照组(n=45)采用奥氮平治疗,观察组(n=45)在对照组基础上进行康复训练.比较两组患者的简易精神状态评估量表(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分、生活质量综合评定问卷(GQOLI-74)评分及治疗总有效率.结果干预前,两组的MMSE和MoCA评分比较,组间差异无统计学意义(P>0.05);干预后,观察组的MMSE、MoCA评分分别为(18.46±3.22)分、(17.66±3.08)分,均高于对照组的(17.09±3.06)分、(16.27±2.84)分,组间差异有统计学意义(P<0.05).干预前,两组的各项GQOLI-74评分比较,组间差异无统计学意义(P>0.05);干预后,观察组的各项GQOLI-74评分均高于对照组,组间差异有统计学意义(P<0.05).观察组的治疗总有效率为91.11%,高于对照组的75.56%,差异有统计学意义(P<0.05).结论奥氮平结合康复训练应用于老年痴呆精神行为障碍患者中,可有效改善其认知功能,提高生活质量,值得临床推广使用.

Objective To analyze the effect of olanzapine combined with rehabilitation training on cognitive function in senile dementia patients with mental and behavioral disorders.Methods A total of 90 patients with senile dementia and mental behavior disorder admitted to our hospital from January 2019 to February 2022 were selected as the research objects and were divided into two groups according to the random number table method.The control group(n=45)received olanzapine treatment,and the observation group(n=45)received rehabilitation training on the basis of the control group.The mini-mental state examination(MMSE)score,Montreal cognitive assessment(MoCA)score,generic quality of life inventory-74(GQOLI-74)score and the total effective rate were compared between the two groups.Results Before intervention,there was no significant difference in MMSE and MoCA scores between the two groups(P>0.05);after intervention,the MMSE and MoCA scores of the observation group were(18.46±3.22)points and(17.66±3.08)points,respectively,which were higher than(17.09±3.06)points and(16.27±2.84)points of the control group,and the differences between the groups were statistically significant(P<0.05).Before intervention,there were no significant differences in GQOLI-74 scores between the two groups(P>0.05);after intervention,the GQOLI-74 scores of the observation group were higher than those of the control group,and the differences between the groups were statistically significant(P<0.05).The total effective rate of the observation group was 91.11%,which was higher than 75.56%of the control group,and the difference was statistically significant(P<0.05).Conclusion Olanzapine combined with rehabilitation training in senile dementia patients with mental and behavioral disorders can effectively improve their cognitive function and quality of life,which is worthy of clinical application.