连续性肾脏替代疗法对重症急性肾衰竭患者肾功能及免疫功能的影响

Effect of Continuous Renal Replacement Therapy on Renal Function and Immune Function in Patients with Severe Acute Renal Failure

目的分析连续性肾脏替代疗法(CRRT)在重症急性肾衰竭患者中的应用效果.方法选取2020年4月—2022年4月该院收治的84例重症急性肾衰竭患者为研究对象,按随机数字表法分为两组,各42例.对照组接受间歇性血液透析治疗,观察组接受CRRT治疗,均治疗2周.对比两组临床疗效、炎症因子水平、肾功能、免疫功能.结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05).治疗前,两组C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、血尿素氮(BUN)、血肌酐(Scr)、CD3^(+)、CD4^(+)、CD8^(+)水平相比,组间差异无统计学意义(P>0.05);治疗后,观察组CRP、TNF-α、IL-6、BUN、Scr、CD8^(+)水平均低于对照组,CD3^(+)、CD4^(+)水平均高于对照组,组间差异有统计学意义(P<0.05).结论CRRT在重症急性肾衰竭患者治疗中的应用效果显著,可有效控制其机体的炎症反应,改善肾功能与免疫功能,临床应用价值高.

Objective To analyze the application effect of continuous renal replacement therapy(CRRT)in patients with severe acute renal failure.Methods 84 patients with severe acute renal failure admitted to the hospital from April 2020 to April 2022 were as the research objects and divided into two groups according to the random number table method,42 patients in each group.The control group received intermittent hemodialysis treatment,and the observation group received CRRT treatment.Both groups received treatment for 2 weeks.The clinical efficacy,inflammatory factor level,renal function and immune function of the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Before treatment,the levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),blood urea nitrogen(BUN),serum creatinine(Scr),CD3^(+),CD4^(+)and CD8^(+)in the two groups were compared,and the differences between the groups were not statistically significant(P>0.05);after treatment,the levels of CRP,TNF-α,IL-6,BUN,Scr and CD8^(+)in the observation group were lower than those in the control group,the levels of CD3^(+)and CD4^(+)were higher than those in the control group,and the differences between the groups were statistically significant(P<0.05).Conclusion The application of CRRT in the treatment of patients with severe acute renal failure has a significant effect,which can effectively control the inflammatory response of the body and improve the renal function and immune function,and has high clinical application value.