毫米波联合康莱特注射液对结直肠癌化疗相关骨髓抑制、免疫功能指标及血管内皮生长因子的影响

Effects of Millimeter Wave Combined with Kanglaite Injection on Chemotherapy-Related Myelosuppression, Immune Function Indexes and Vascular Endothelial Growth Factor in Colorectal Cancer

目的探讨毫米波联合康莱特注射液对结直肠癌化疗相关骨髓抑制、免疫功能指标及血管内皮生长因子(VEGF)的影响.方法选取2020年1月-2021年1月我院收治的33例结直肠癌患者,将患者随机分为对照组16例与观察组17例.对照组行化疗联合毫米波治疗,观察组在对照组基础上联合康莱特注射液治疗.比较两组临床疗效、治疗前和治疗4周后骨髓抑制指标、免疫功能指标、VEGF水平.结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05).两组治疗前白细胞(WBC)、血红蛋白(Hb)、血小板(PLT)水平比较,组间差异无统计学意义(P>0.05);治疗后,观察组WBC、Hb、PLT水平均高于对照组,组间差异有统计学意义(P<0.05).治疗前,两组自然杀伤细胞(NK)、CD4^(+)、CD8^(+)、CD3^(+)水平相比,组间差异无统计学意义(P>0.05);治疗后,观察组NK、CD4^(+)、CD3^(+)水平均高于对照组,CD8^(+)水平低于对照组,组间差异有统计学意义(P<0.05);治疗前,两组VEGF-A、VEGF-C、VEGF-D水平比较,组间差异无统计学意义(P>0.05),治疗后,观察组VEGF-A、VEGF-C、VEGF-D水平均低于对照组,组间差异有统计学意义(P<0.05).结论毫米波联合康莱特注射液用于结直肠癌患者化疗中疗效确切,可减轻骨髓抑制,提高机体免疫功能,降低血管内皮生长因子水平,值得临床推广应用.

Objective To investigate the effect of millimeter wave combined with Kanglaite injection on chemotherapyrelated myelosuppression,immune function indexes and vascular endothelial growth factor(VEGF)in colorectal cancer.Methods A total of 33 patients with colorectal cancer who were admitted to our hospital from January 2020 to January 2021 were selected and were randomly divided into a control group of 16 cases and an observation group of 17 cases.The control group were treated with chemotherapy combined with millimeter wave treatment,and the observation group were treated with Kanglaite injection on the basis of the control group.The clinical efficacy,myelosuppression indexes,immune func tion indexes and VEGF levels before and after 4 weeks of treatment were compared between the two groups.Results The total effective rate of treatment of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There were no significant differences in the levels of white blood cells(WBC),hemoglobin(Hb)and platelets(PLT)between the two groups before treatment(P>0.05);after treatment,the levels of WBC,Hb and PLT in the observation group were higher than those in the control group,and the differences between the groups were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of natural killer cells(NK),CD4^(+),CD8^(+)and CD3^(+)between the two groups(P>0.05);after treatment,the levels of NK,CD4^(+)and CD3^(+)in the observation group were higher than those in the control group,and the level of CD8^(+)was lower than that in the control group,and the differences between the groups were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of VEGF-A,VEGF-C and VEGF-D between the two groups(P>0.05);after treatment,the levels of VEGF-A,VEGF-C and VEGF-D in the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).Conclusion Millimeter wave combined with Kanglaite injection is effective in chemotherapy of patients with colorectal cancer.It can relieve myelosuppression,improve immune function,reduce the level of VEGF.It is worthy of clinical application.