越鞠丸联合经颅微电流刺激治疗肝郁气滞型卒中后抑郁的临床效果观察

Clinical Observation of Yueju Pill Combined with Transcranial Microcurrent Stimulation in the Treatment of Post-Stroke Depression due to Liver Stagnation and Qi Stagnation

目的探讨越鞠丸联合经颅微电流刺激(CES)治疗肝郁气滞型卒中后抑郁的临床效果.方法选择2020年4月-2022年3月我院收治的108例肝郁气滞型卒中后抑郁患者,按随机数字表法分为三组,每组36例.对照组采用常规西药治疗,越鞠丸组在对照组基础上采用越鞠丸治疗,越鞠丸联合CES组在越鞠丸组基础上联合CES治疗.比较三组中医证候积分、汉密尔顿焦虑量表(HAMD)评分、美国国立卫生研究院卒中量表(NIHSS)评分及日常生活活动能力量表(ADL)评分.结果治疗后,三组中医证候积分、HAMD、NIHSS评分均低于治疗前,ADL评分均高于治疗前,且越鞠丸联合CES组中医证候积分、HAMD、NIHSS评分均低于越鞠丸组、对照组,ADL评分均高于越鞠丸组、对照组;越鞠丸组中医证候积分、HAMD、NIHSS评分均低于对照组,ADL评分高于对照组,组间差异有统计学意义(P<0.05).三组均未出现严重不良反应.结论肝郁气滞型卒中后抑郁患者采用越鞠丸联合CES的治疗效果较好,能够明显改善患者抑郁症状,提高神经功能与日常生活能力,且安全性较高,值得临床广泛应用.

Objective To investigate the clinical effect of Yueju Pill combined with transcranial microcurrent stimulation(CES)in the treatment of post-stroke depression with liver stagnation and qi stagnation.Methods A total of 108 patients with post-stroke depression in our hospital from April 2020 to March 2022 were selected and divided into 3 groups according to the random number table method,with 36 cases in each group.The control group was treated with conventional western medicine,the Yueju Pill group was treated with Yueju Pill on the basis of the control group,and the Yueju Pill combined with CES group was treated with CES on the basis of the Yueju Pill group.The scores of TCM syndromes,Hamilton anxiety scale(HAMD),National Institutes of health stroke scale(NIHSS)and activities of daily living(ADL)were compared among the three groups.Results After treatment,the TCM syndrome scores,HAMD and NIHSS scores of the three groups were lower than those before treatment,and the ADL scores were higher than those before treatment,and the TCM syndrome scores,HAMD and NIHSS scores of Yueju Pill combined with CES group were lower than those of Yueju Pill group and control group,and the ADL score was higher than that of Yueju Pill group and control group;TCM syndrome scores,HAMD and NIHSS scores in Yueju Pill group were lower than those in control group,ADL score was higher than that in control group,and the differences between groups were statistically significant(P<0.05).There were no serious adverse reactions in the three groups.Conclusion The treatment effect of Yueju Pill combined with CES in post-stroke depression patients with liver stagnation and qi stagnation is better,which can significantly improve the symptoms of depression,improve neurological function and daily living ability,and has high safety,which is worthy of wide clinical application.