介入取栓术后西洛他唑联合阿司匹林辅助治疗急性缺血性脑卒中的临床效果

Clinical Effect of Cilostazol Combined with Aspirin Adjuvant Therapy in Acute Ischemic Stroke after Interventional Thrombectomy

目的探讨介入取栓术后西洛他唑联合阿司匹林辅助治疗急性缺血性脑卒中(AIS)的临床效果.方法选取2020年5月—2021年5月我院收治的30例AIS患者为研究对象,随机分为对照组和观察组,各15例.所有患者行介入取栓治疗,对照组介入术后给予氯吡格雷辅助治疗,观察组介入术后采用西洛他唑联合阿司匹林辅助治疗.对比两组的临床疗效、血小板(PLT)计数、认知功能、出血事件、脑血管再闭塞发生率.结果观察组的治疗总有效率高于对照组,差异有统计学意义(P<0.05).治疗90 d后,观察组的PLT计数低于对照组,差异有统计学意义(P<0.05).治疗60、90 d后,观察组的北京版蒙特利尔认知评估量表评分高于对照组,组间差异有统计学意义(P<0.05).两组的总出血事件、脑血管再闭塞发生率对比,组间差异无统计学意义(P>0.05).结论介入取栓术后采用西洛他唑联合阿司匹林辅助治疗AIS有较好的抗血小板聚集作用,能提高临床疗效,促进患者的认知功能恢复,且不会增加出血事件和脑血管再闭塞的发生.

Objective To investigate the clinical effect of cilostazol combined with aspirin adjuvant therapy in acute ischemic stroke(AIS)after interventional thrombectomy.Methods A total of 30 patients with AIS who were admitted to our hospital from May 2020 to May 2021 were selected as the research objects,and they were randomly divided into a control group and an observation group,with 15 cases in each group.All patients received interventional thrombectomy therapy,the control group received clopidogrel adjuvant therapy after intervention,and the observation group received cilostazol combined with aspirin adjuvant therapy after intervention.The clinical efficacy,platelets(PLT)count,cognitive function,bleeding events and cerebral vascular reocclusion rate were compared between the two groups.Results The total effective rate of treatment of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After 90 days of treatment,the PLT count in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).After 60 d and 90 d of treatment,the Beijing version of Montreal cognitive assessment score in the observation group was higher than those in the control group,and the differences between the groups were statistically significant(P<0.05).There were no significant differences in total bleeding events and cerebral vascular reocclusion rates between the two groups(P>0.05).Conclusion After interventional thrombectomy,cilostazol combined with aspirin adjuvant therapy in AIS has a good anti-platelet aggregation effect,can improve the clinical efficacy,promote the recovery of cognitive function of patients,without increasing the occurrence of bleeding events and cerebral vascular reocclusion.