低频重复经颅磁刺激联合柴胡加龙骨牡蛎汤加减治疗原发性失眠的疗效评价

Efficacy Evaluation of Low Frequency Repetitive Transcranial Magnetic Stimulation Combined with Modified Chaihu Plus Longgu Muli Decoction in the Treatment of Primary Insomnia

目的探讨原发性失眠患者采用低频重复经颅磁刺激(rTMS)联合柴胡加龙骨牡蛎汤加减治疗的临床效果.方法选取本院2021年1月—2022年2月收治的90例原发性失眠患者为研究对象,按随机数字表法分为两组.对照组45例采用常规西药治疗,观察组45例采用低频rTMS联合柴胡加龙骨牡蛎汤加减治疗.比较两组治疗前和治疗30 d后的中医证候积分、匹兹堡睡眠质量指数(PSQI)评分.结果治疗前,两组的中医证候积分及PSQI评分比较,组间差异无统计学意义(P>0.05);治疗30 d后,观察组的中医证候积分、PSQI评分分别为(10.41±2.57)分、(6.36±1.72)分,均低于对照组的(16.32±4.01)分、(12.33±2.42)分,组间差异有统计学意义(P<0.05).结论原发性失眠患者采用低频rTMS联合柴胡加龙骨牡蛎汤加减治疗可有效改善失眠症状,提高睡眠质量,疗效显著.

Objective To explore the clinical effect of low frequency repetitive transcranial magnetic stimulation(rTMS)combined with modified Chaihu plus Longgu Muli Decoction in the treatment of primary insomnia.Methods A total of 90 patients with primary insomnia admitted to our hospital from January 2021 to February 2022 were selected as the research objects and were divided into two groups by random number table method.The 45 cases in the control group were treated with conventional western medicine,while the 45 ccases in the observation group were treated with low frequency rTMS combined with modified Chaihu plus Longgu Muli Decoction.The TCM syndrome scores and Pittsburgh sleep quality index(PSQI)scores before and 30 days after treatment were compared between the two groups.Results Before treatment,there were no significant differences in TCM syndrome scores and PSQI scores between the two groups(P>0.05);after 30 days of treatment,the TCM syndrome score and PSQI score of the observation group were(10.41±2.57)points and(6.36±1.72)points,respectively,which were lower than(16.32±4.01)points and(12.33±2.42)points of the control group,and the differences between the groups were statistically significant(P<0.05).Conclusion Low frequency rTMS combined with modified Chaihu plus Longgu Muli Decoction can effectively improve insomnia symptoms and sleep quality in patients with primary insomnia.