小儿急性扁桃体炎应用复方芩兰口服液治疗的效果及对患儿炎症因子水平的影响研究

Study on the Effect of Treatment of Pediatric Acute Tonsillitis with Compound Scutellaria Oral Liquid and the Effect on the Level of Inflammatory Factors in Children

目的分析小儿急性扁桃体炎应用复方芩兰口服液治疗的效果及对患儿炎症因子水平的影响.方法选取该院2021年3月—2022年4月收治的122例急性扁桃体炎患儿,按照随机数字表法分为两组.对照组61例采用常规药物治疗,观察组61例在对照组基础上采用复方芩兰口服液治疗.对比两组临床疗效,临床症状消失时间,炎症因子及免疫功能指标水平.结果观察组治疗总有效率为96.72%,较对照组的81.97%高,差异有统计学意义(P<0.05).观察组发热消退、扁桃体肿大、咽部疼痛消失时间分别为(29.48±5.92)h、(41.92±6.25)h、(36.82±5.22)h,均短于对照组,组间差异有统计学意义(P<0.05).治疗后,观察组CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组,CD8^(+)水平低于对照组,组间差异有统计学意义(P<0.05).治疗后,观察组超敏C反应蛋白、白细胞介素-6、降钙素原分别为(2.51±0.21)mg/L、(11.36±2.31)ng/L、(1.53±0.21)ng/mL,均低于对照组,组间差异有统计学意义(P<0.05).结论小儿急性扁桃体炎采用复方芩兰口服液治疗的效果确切,能尽快缓解患儿症状,缩短症状消失时间,降低炎症因子水平,提高患儿免疫能力,具有较高的临床应用价值.

Objective To analyze the effect of applying compound Scutellaria oral liquid in the treatment of pediatric acute tonsillitis and the effect on the level of inflammatory factors in children.Methods 122 cases of children with acute tonsillitis admitted to the hospital from March 2021 to April 2022 were selected and divided into two groups according to the random number table method.61 cases in the control group were treated with conventional drugs,and 61 cases in the observation group were treated with compound Scutellaria oral liquid on the basis of the control group.The clinical efficacy,the disappearance time of clinical symptoms,the level of inflammatory factors and immune function indexes of the two groups were compared.Results The total effective rate of treatment in the observation group was 96.72%,which was higher than 81.97%in the control group,and the difference was statistically significant(P<0.05).The time of fever subsiding,tonsillar enlargement and pharyngeal pain disappearing in the observation group were(29.48±5.92)h,(41.92±6.25)h and(36.82±5.22)h,respectively,which were shorter than those in the control group,and the differences between groups were statistically significant(P<0.05).After treatment,the CD4^(+)and CD4^(+)/CD8^(+)levels in the observation group were higher than those in the control group,and the CD8^(+)level was lower than that in the control group,and the differences between groups were statistically significant(P<0.05).After treatment,hypersensitive C-reactive protein,interleukin-6 and calcitoninogen were(2.51±0.21)mg/L,(11.36±2.31)ng/L and(1.53±0.21)ng/mL in the observation group,respectively,which were lower than those in the control group,and the differences between groups were statistically significant(P<0.05).Conclusion The treatment of pediatric acute tonsillitis with compound Scutellaria oral liquid has exact effect,which can relieve the symptoms of children as soon as possible,shorten the time of disappearance symptoms,reduce the level of inflammatory factors and improve the immunity of children,and has high clinical application value.