丁苯酞联合阿托伐他汀对脑梗死后轻度认知功能障碍患者认知功能及智力恢复情况的影响

Effects of Butylphthalide Combined with Atorvastatin on Cognitive Function and Mental Recovery in Patients with Mild Cognitive Impairment after Cerebral Infarction

目的探讨丁苯酞联合阿托伐他汀在脑梗死后轻度认知功能障碍(MCI)患者中的应用效果.方法选择2019年7月—2021年6月该院收治的脑梗死后MCI患者160例,按随机数字表法分为两组,各80例.对照组采用常规治疗,观察组在此基础上采用丁苯酞联合阿托伐他汀治疗,均持续治疗8周.对比两组的认知功能、智力恢复情况、脑血流灌注指标及不良反应发生情况.结果观察组治疗后的蒙特利尔认知评估量表中文版评分、简易精神状态检查表评分分别为(24.92±3.40)分、(24.58±3.40)分,均高于对照组的(22.15±3.31)分、(21.62±3.38)分,组间差异有统计学意义(P<0.05).观察组治疗后的脑血容量、脑血流量分别为(1.36±0.23)×10^(-2)mL/g、(0.93±0.21)×10^(-2)mL/(g·min),均高于对照组的(1.22±0.25)×10^(-2)mL/g、(0.78±0.18)×10^(-2)mL/(g·min),平均通过时间(1.05±0.14)s短于对照组的(1.25±0.17)s,组间差异有统计学意义(P<0.05).两组不良反应发生率相比,差异无统计学意义(P>0.05).结论丁苯酞联合阿托伐他汀在脑梗死后MCI患者中具有较好的应用效果,可提升患者认知功能,改善脑血流灌注,且不良反应较少,安全性高.

Objective To investigate the application effect of butylphthalide combined with atorvastatin in patients with mild cognitive impairment(MCI)after cerebral infarction.Methods A total of 160 patients with MCI after cerebral infarction admitted to our hospital from July 2019 to June 2021 were selected and divided into two groups according to the random number table method,with 80 cases in each group.The control group was given routine treatment,and the observation group was given butylphthalide combined with atorvastatin treatment on this basis,and the treatment was continued for 8 weeks.The cognitive function,mental recovery,cerebral blood perfusion indexes and adverse reactions were compared between the two groups.Results The post-treatment scores of the Chinese version of the Montreal Cognitive Assessment Scale and the minimental state examination in the observation group were(24.92±3.40)points and(24.58±3.40)points,respectively,which were higher than those of the control group(22.15±3.31)points and(21.62±3.38)points,and the differences between the groups were statistically significant(P<0.05).The cerebral blood volume and cerebral blood flow in the observation group after treatment were(1.36±0.23)×10^(-2)mL/g and(0.93±0.21)×10^(-2)mL/(g·min),respectively,which were higher than those in the control group(1.22±0.25)×10^(-2)mL/g and(0.78±0.18)×10^(-2)mL/(g·min),and the mean passage time(1.05±0.14)s was shorter than that of the control group(1.25±0.17)s,the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Butylphthalide combined with atorvastatin has a good application effect in MCI patients after cerebral infarction,can improve the cognitive function of patients,improve cerebral blood perfusion,and has fewer adverse reactions and high safety.