雾化吸入康复治疗联合孟鲁斯特应用于小儿感染后咳嗽的临床效果观察

Clinical Effect Observation of Atomized Inhalation Rehabilitation Combined with Montelukast in Children with Post Infection Cough

目的探讨小儿感染后咳嗽使用雾化吸入康复治疗联合孟鲁斯特的临床疗效.方法将本院2019年10月—2020年10月收治的102例感染后咳嗽患儿纳为研究对象,以随机抽签的方式将其均分成两组,每组51例.对照组患儿采用孟鲁斯特治疗,观察组患儿采用孟鲁斯特联合雾化吸入康复治疗.对比两组的临床治疗效果.结果观察组的治疗总有效率为98.04%,高于对照组的86.27%,差异有统计学意义(P<0.05).治疗后,观察组的白细胞介素6、肿瘤坏死因子α、C-反应蛋白水平均低于对照组,组间差异有统计学意义(P<0.05).观察组治疗3、5、7、10 d的咳嗽症状积分均低于对照组,组间差异有统计学意义(P<0.05).观察组的气喘、咽痛、咳嗽、发热消失时间均短于对照组,组间差异有统计学意义(P<0.05).观察组的不良反应发生率为3.92%,明显低于对照组的15.69%,差异有统计学意义(P<0.05).结论感染后咳嗽患儿采用孟鲁斯特联合雾化吸入康复治疗,可显著降低炎性因子水平,缩短症状改善时间,提升整体疗效,且不良反应相对更少,因此安全性更高,值得临床普及使用.

Objective To investigate the clinical effect of atomized inhalation rehabilitation combined with montelukast in children with cough after infection.Methods 102 children with post infection cough admitted to the hospital from October 2019 to October 2020 were selected as the study subjects,and they were randomly divided into two groups,with 51 cases in each group.The control group was treated with montelukast,and the observation group was treated with montelukast combined with atomized inhalation rehabilitation.The clinical therapeutic effects of the two groups were compared.Results The total effective rate of the observation group was 98.04%,higher than 86.27%of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)in the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).The scores of cough symptoms in the observation group were lower than those in the control group on day 3,5,7 and 10 of treatment,and the differences between the groups were statistically significant(P<0.05).The disappearance time of asthma,sore throat,cough and fever in the observation group were shorter than those in the control group,and the differences between the groups were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 3.92%,which was significantly lower than 15.69%in the control group,the difference was statistically significant(P<0.05).Conclusion Montelukast combined with atomized inhalation rehabilitation therapy for children with post infection cough can significantly reduce the level of inflammatory factors,shorten the time for symptom improvement,improve the overall efficacy,and have fewer adverse reactions,so it is safer and worthy of clinical popularization.