卡前列素氨丁三醇和缩宫素治疗产后出血的效果及对出血量的影响

Effect of Carboprost Tromethamine and Oxytocin in the Treatment of Postpartum Hemorrhage and its Influence on the Amount of Bleeding

目的探讨卡前列素氨丁三醇和缩宫素治疗产后出血的临床疗效.方法选取2020年1月—2021年9月我院收治的98例产后出血产妇为研究对象,按随机数字表法将其分为两组,每组49例.对照组采用缩宫素治疗,研究组在此基础上加用卡前列素氨丁三醇治疗.对比两组的临床疗效、出血量、止血起效时间、凝血功能及不良反应发生情况.结果研究组的治疗总有效率为95.92%,高于对照组的81.63%,差异有统计学意义(P<0.05).研究组的出血量为(267.33±25.50)mL,少于对照组的(318.66±31.91)mL,止血起效时间为(8.19±1.67)min,短于对照组的(15.86±3.50)min,组间差异有统计学意义(P<0.05).治疗前,两组的各项凝血功能指标比较,组间差异无统计学意义(P>0.05);治疗后,研究组的纤维蛋白原为(3.77±0.43)g/L,D-二聚体为(2.25±0.36)mg/L,凝血酶原时间为(13.96±1.40)s、部分凝血活酶时间为(27.73±1.45)s、凝血酶时间为(17.02±1.04)s,均优于对照组,组间差异有统计学意义(P<0.05).两组的不良反应发生率比较,差异无统计学意义(P>0.05).结论卡前列素氨丁三醇联合缩宫素治疗产后出血的效果确切,可减少出血,改善凝血功能,且不良反应少,值得临床推广使用.

Objective To investigate the clinical effect of carboprost tromethamine and oxytocin in the treatment of postpartum hemorrhage.Methods A total of 98 cases of puerpera with postpartum hemorrhage admitted to our hospital from January 2020 to September 2021 were selected as the research objects,and were divided into two groups according to random number table method,with 49 cases in each group.The clinical efficacy,blood loss,effective hemostasis time,coagulation function and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the study group was 95.92%,which was higher than 81.63%of the control group,the difference was statistically significant(P<0.05).The blood loss in the study group was(267.33±25.50)mL,less than(318.66±31.91)mL in the control group,and the hemostasis effect time was(8.19±1.67)min,shorter than(15.86±3.50)min in the control group,the differences between the groups were statistically significant(P<0.05).There were no significant differences in coagulation function indexes between the two groups before treatment(P>0.05);after treatment,the fibrin of the study group was(3.77±0.43)g/L,D-dimer was(2.25±0.36)mg/L,prothrombin time was(13.96±1.40)s,partial thrombin time was(27.73±1.45)s,thrombin time was(17.02±1.04)s,which were better than those of the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The effect of carboprost tromethamine combined with oxytocin in the treatment of postpartum hemorrhage is accurate,can reduce bleeding,improve coagulation function,and has few adverse reactions,which is worthy of clinical application.